9sa2

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m (Protected "9sa2" [edit=sysop:move=sysop])
Current revision (04:20, 14 September 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9sa2 is ON HOLD
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==The RING domain of IDOL==
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<StructureSection load='9sa2' size='340' side='right'caption='[[9sa2]], [[Resolution|resolution]] 1.10&Aring;' scene=''>
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Authors: Bradshaw, W.J., He, L., Guenther, F., Murphy, E.J.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9sa2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9SA2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9SA2 FirstGlance]. <br>
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Description: The RING domain of IDOL
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.1&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Bradshaw, W.J]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9sa2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9sa2 OCA], [https://pdbe.org/9sa2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9sa2 RCSB], [https://www.ebi.ac.uk/pdbsum/9sa2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9sa2 ProSAT]</span></td></tr>
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[[Category: Guenther, F]]
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</table>
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[[Category: Murphy, E.J]]
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== Function ==
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[[Category: He, L]]
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[https://www.uniprot.org/uniprot/MYLIP_HUMAN MYLIP_HUMAN] E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR.<ref>PMID:10593918</ref> <ref>PMID:14550572</ref> <ref>PMID:12826659</ref> <ref>PMID:19520913</ref> <ref>PMID:20427281</ref> <ref>PMID:22109552</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Bradshaw WJ]]
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[[Category: Guenther F]]
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[[Category: He L]]
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[[Category: Murphy EJ]]

Current revision

The RING domain of IDOL

PDB ID 9sa2

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OCA

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