7jjk
From Proteopedia
(Difference between revisions)
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<StructureSection load='7jjk' size='340' side='right'caption='[[7jjk]], [[Resolution|resolution]] 1.40Å' scene=''> | <StructureSection load='7jjk' size='340' side='right'caption='[[7jjk]], [[Resolution|resolution]] 1.40Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'> | + | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7JJK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7JJK FirstGlance]. <br> |
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4Å</td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7jjk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jjk OCA], [https://pdbe.org/7jjk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7jjk RCSB], [https://www.ebi.ac.uk/pdbsum/7jjk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7jjk ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7jjk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jjk OCA], [https://pdbe.org/7jjk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7jjk RCSB], [https://www.ebi.ac.uk/pdbsum/7jjk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7jjk ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | == Function == | ||
| - | [https://www.uniprot.org/uniprot/SOX30_HUMAN SOX30_HUMAN] Acts as both a transcriptional activator and repressor (PubMed:10359848, PubMed:29739711). Binds to the DNA sequence 5'-ACAAT-3' and shows a preference for guanine residues surrounding this core motif (PubMed:10359848). Binds to its own promoter and activates its own transcription (By similarity). Required to activate the expression of postmeiotic genes involved in spermiogenesis (By similarity). Binds to the promoter region of CTNNB1 and represses its transcription which leads to inhibition of Wnt signaling (PubMed:29739711). Also inhibits Wnt signaling by binding to the CTNNB1 protein, preventing interaction of CTNNB1 with TCF7L2/TCF4 (PubMed:29739711).[UniProtKB:Q8CGW4]<ref>PMID:10359848</ref> <ref>PMID:29739711</ref> | ||
| - | == References == | ||
| - | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Forwood JK]] | [[Category: Forwood JK]] | ||
[[Category: Ghafoori SM]] | [[Category: Ghafoori SM]] | ||
Current revision
Crystal structure of SOX30
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