7qry
From Proteopedia
(Difference between revisions)
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<StructureSection load='7qry' size='340' side='right'caption='[[7qry]], [[Resolution|resolution]] 2.07Å' scene=''> | <StructureSection load='7qry' size='340' side='right'caption='[[7qry]], [[Resolution|resolution]] 2.07Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'> | + | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QRY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QRY FirstGlance]. <br> |
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.07Å</td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.07Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qry FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qry OCA], [https://pdbe.org/7qry PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qry RCSB], [https://www.ebi.ac.uk/pdbsum/7qry PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qry ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qry FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qry OCA], [https://pdbe.org/7qry PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qry RCSB], [https://www.ebi.ac.uk/pdbsum/7qry PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qry ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | == Disease == | ||
| - | [https://www.uniprot.org/uniprot/TRI18_HUMAN TRI18_HUMAN] Defects in MID1 are the cause of Opitz GBBB syndrome 1 (OGS1) [MIM:[https://omim.org/entry/300000 300000]. A congenital midline malformation syndrome characterized by hypertelorism, genital-urinary defects such as hypospadias in males and splayed labia in females, lip-palate-laryngotracheal clefts, imperforate anus, developmental delay and congenital heart defects. Note=MID1 mutations produce proteins with a decreased affinity for microtubules.<ref>PMID:9354791</ref> <ref>PMID:11030761</ref> <ref>PMID:9718340</ref> <ref>PMID:15558842</ref> | ||
| - | == Function == | ||
| - | [https://www.uniprot.org/uniprot/TRI18_HUMAN TRI18_HUMAN] Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination.<ref>PMID:10400985</ref> <ref>PMID:11685209</ref> <ref>PMID:22613722</ref> | ||
==See Also== | ==See Also== | ||
*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]] | *[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]] | ||
| - | == References == | ||
| - | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Chaikuad A]] | [[Category: Chaikuad A]] | ||
[[Category: Knapp S]] | [[Category: Knapp S]] | ||
Current revision
Crystal structure of B30.2 PRYSPRY domain of MID1
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