1wlh
From Proteopedia
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'''Molecular structure of the rod domain of Dictyostelium filamin''' | '''Molecular structure of the rod domain of Dictyostelium filamin''' | ||
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[[Category: Popowicz, G M.]] | [[Category: Popowicz, G M.]] | ||
[[Category: Schleicher, M.]] | [[Category: Schleicher, M.]] | ||
| - | [[Category: | + | [[Category: Abp-120]] |
| - | [[Category: | + | [[Category: Filamin]] |
| - | [[Category: | + | [[Category: Immunoglobulin fold]] |
| - | [[Category: | + | [[Category: Rod domain]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:50:24 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 10:50, 3 May 2008
Molecular structure of the rod domain of Dictyostelium filamin
Overview
Dictyostelium discoideum filamin (ddFLN) is a two-chain F-actin crosslinking protein with an N-terminal actin-binding domain and a rod domain constructed from six tandem repeats of a 100 residue motif that has an immunoglobulin (Ig) fold. We report the 2.8 A resolution crystal structure of a homodimer of rod repeats 4, 5 and 6. The two chains are arranged in an antiparallel fashion and form an elongated element, which is shortened, however, compared to a fully extended, linear configuration because the long axis of each Ig domain is arranged at an angle to the long axis of the rod. Same arrangement of repeats should also be present in the rod domain of human FLNa, much longer than Dictyostelium FLN, which forms an extended structure able to crosslink F-actin chains over distances of more than 1000 A.
About this Structure
1WLH is a Single protein structure of sequence from Dictyostelium discoideum. Full crystallographic information is available from OCA.
Reference
Molecular structure of the rod domain of dictyostelium filamin., Popowicz GM, Muller R, Noegel AA, Schleicher M, Huber R, Holak TA, J Mol Biol. 2004 Oct 1;342(5):1637-46. PMID:15364587 Page seeded by OCA on Sat May 3 13:50:24 2008
