9dkp
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | The | + | ==The structure of human vacuolar protein sorting 34 catalytic domain bound to RD-I-53== |
| - | + | <StructureSection load='9dkp' size='340' side='right'caption='[[9dkp]], [[Resolution|resolution]] 2.16Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9dkp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9DKP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9DKP FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.16Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1A6F:(8R)-3-(1,3-benzothiazol-2-yl)pyrazolo[1,5-a]pyrimidine'>A1A6F</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=ETX:2-ETHOXYETHANOL'>ETX</scene>, <scene name='pdbligand=ETZ:DIETHYL+ETHER'>ETZ</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9dkp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9dkp OCA], [https://pdbe.org/9dkp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9dkp RCSB], [https://www.ebi.ac.uk/pdbsum/9dkp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9dkp ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/PK3C3_HUMAN PK3C3_HUMAN] Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis. Required for transport from early to late endosomes.<ref>PMID:7628435</ref> <ref>PMID:14617358</ref> <ref>PMID:20208530</ref> |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Abiodun WO]] | ||
| + | [[Category: Dass R]] | ||
| + | [[Category: Doukov T]] | ||
| + | [[Category: Moody JD]] | ||
| + | [[Category: Peterson MA]] | ||
| + | [[Category: Samarawickrama P]] | ||
| + | [[Category: Singleton JD]] | ||
| + | [[Category: Tsubaki E]] | ||
Current revision
The structure of human vacuolar protein sorting 34 catalytic domain bound to RD-I-53
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