9gki
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of 5mer pore intermediate of Sticholysin II (StnII) toxin in lipid nanodiscs== | |
| - | + | <StructureSection load='9gki' size='340' side='right'caption='[[9gki]], [[Resolution|resolution]] 3.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9gki]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Stichodactyla_helianthus Stichodactyla helianthus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9GKI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9GKI FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.8Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9gki FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9gki OCA], [https://pdbe.org/9gki PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9gki RCSB], [https://www.ebi.ac.uk/pdbsum/9gki PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9gki ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: Carlero | + | == Function == |
| - | [[Category: Martin Benito | + | [https://www.uniprot.org/uniprot/ACTP2_STIHL ACTP2_STIHL] Pore-forming protein that forms cations-selective hydrophilic pores of around 1 nm and causes cardiac stimulation and hemolysis. Pore formation is a multi-step process that involves specific recognition of membrane sphingomyelin (but neither cholesterol nor phosphatidylcholine) using aromatic rich region and adjacent phosphocholine (POC) binding site, firm binding to the membrane (mainly driven by hydrophobic interactions) accompanied by the transfer of the N-terminal region to the lipid-water interface and finally pore formation after oligomerization of several monomers. Cytolytic effects include red blood cells hemolysis, platelet aggregation and lysis, cytotoxic and cytostatic effects on fibroblasts. Lethality in mammals has been ascribed to severe vasospasm of coronary vessels, cardiac arrhythmia, and inotropic effects.<ref>PMID:10978735</ref> <ref>PMID:11478962</ref> |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Stichodactyla helianthus]] | ||
| + | [[Category: Carlero D]] | ||
| + | [[Category: Martin Benito J]] | ||
| + | [[Category: Santiago C]] | ||
Current revision
Structure of 5mer pore intermediate of Sticholysin II (StnII) toxin in lipid nanodiscs
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