9qen

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Current revision (05:42, 17 September 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9qen is ON HOLD until Paper Publication
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==Cryo-EM structure of human O-GlcNAcase==
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<StructureSection load='9qen' size='340' side='right'caption='[[9qen]], [[Resolution|resolution]] 3.08&Aring;' scene=''>
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Authors: Basse Hansen, S., Bartual, S.G., Yuan, H., Raimi, O.G., Gorelik, A., Ferenbach, A.T., Lytje, K., Pedersen, J.S., Drace, T., Boesen, T., van Aalten, D.M.F.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9qen]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9QEN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9QEN FirstGlance]. <br>
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Description: Cryo-EM structure of human O-GlcNAcase
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.08&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9qen FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9qen OCA], [https://pdbe.org/9qen PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9qen RCSB], [https://www.ebi.ac.uk/pdbsum/9qen PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9qen ProSAT]</span></td></tr>
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[[Category: Pedersen, J.S]]
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</table>
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[[Category: Boesen, T]]
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== Function ==
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[[Category: Lytje, K]]
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[https://www.uniprot.org/uniprot/OGA_HUMAN OGA_HUMAN] Isoform 1: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro) (PubMed:11148210). Does not bind acetyl-CoA and does not have histone acetyltransferase activity (PubMed:24088714).<ref>PMID:11148210</ref> <ref>PMID:11788610</ref> <ref>PMID:20673219</ref> <ref>PMID:22365600</ref> <ref>PMID:24088714</ref> Isoform 3: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc as substrate but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro), but has about six times lower specific activity than isoform 1.<ref>PMID:20673219</ref>
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[[Category: Yuan, H]]
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== References ==
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[[Category: Basse Hansen, S]]
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<references/>
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[[Category: Bartual, S.G]]
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__TOC__
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[[Category: Gorelik, A]]
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</StructureSection>
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[[Category: Van Aalten, D.M.F]]
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[[Category: Homo sapiens]]
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[[Category: Raimi, O.G]]
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[[Category: Large Structures]]
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[[Category: Ferenbach, A.T]]
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[[Category: Bartual SG]]
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[[Category: Drace, T]]
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[[Category: Basse Hansen S]]
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[[Category: Boesen T]]
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[[Category: Drace T]]
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[[Category: Ferenbach AT]]
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[[Category: Gorelik A]]
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[[Category: Lytje K]]
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[[Category: Pedersen JS]]
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[[Category: Raimi OG]]
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[[Category: Yuan H]]
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[[Category: Van Aalten DMF]]

Current revision

Cryo-EM structure of human O-GlcNAcase

PDB ID 9qen

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OCA

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