Hydroxylases 3D structures

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Current revision (07:00, 17 September 2025) (edit) (undo)
 
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**[2toh]], [[1toh]] – rTH catalytic and tetramerization domains 160-498 – rat
**[2toh]], [[1toh]] – rTH catalytic and tetramerization domains 160-498 – rat
**[[2mda]] – rTH regulatory domain 65-159 – NMR<br />
**[[2mda]] – rTH regulatory domain 65-159 – NMR<br />
-
**[[7kqr]], [[7kqs]], [[7kqt]], [[7kqu]] – TH + heme + Tyr derivative – ''Streptomyces sclerotialus'' <br />
+
**[[8r2s]] – SsTH (mutant) + heme – ''Streptomyces sclerotialus'' <br />
 +
**[[7kqr]], [[7kqs]], [[7kqt]], [[7kqu]], [[8vmk]] – SsTH + heme + Tyr derivative <br />
*Tryptophan hydroxylase
*Tryptophan hydroxylase
**[[7wiy]] – hTPH 2 + Fe – Cryo EM<br />
**[[7wiy]] – hTPH 2 + Fe – Cryo EM<br />
-
**[[3hf8]], [[3hfb]], [[3hf6]], [[5tpg]], [[5l01]], [[5j6d]], [[7zig]], [[7zih]], [[7zif]], [[7zii]], [[7zij]], [[9he3]] – hTPH 1 catalytic domain 105-401 + inhibitor + Fe <br />
+
**[[3hf8]], [[3hfb]], [[3hf6]], [[5tpg]], [[5l01]], [[5j6d]], [[7zig]], [[7zih]], [[7zif]], [[7zii]], [[7zij]], [[7zik]], [[8cji]], [[8cjj]], [[8cjk]], [[8cjl]], [[8cjm]], [[8cjn]], [[8cjo]] – hTPH 1 catalytic domain 105-401 + inhibitor + Fe <br />
**[[1mlw]] – hTPH catalytic domain+ biopterin + Fe<br />
**[[1mlw]] – hTPH catalytic domain+ biopterin + Fe<br />
**[[4v06]] - hTPH 2 catalytic domain + Fe<br />
**[[4v06]] - hTPH 2 catalytic domain + Fe<br />
 +
**[[8hb7]], [[9hb8]] - hTPH 2 catalytic domain + Fe + inhibitor<br />
**[[7qri]] - hTPH 2 regulatory domain 48-145 + Phe - NMR<br />
**[[7qri]] - hTPH 2 regulatory domain 48-145 + Phe - NMR<br />
**[[3e2t]] – TPH 1 catalytic domain + Trp + Fe – chicken
**[[3e2t]] – TPH 1 catalytic domain + Trp + Fe – chicken
Line 67: Line 69:
**[[1dod]], [[1doe]], [[1iuv]], [[1iuw]], [[1iux]] – PaPHBH + FAD + DHB derivative<br />
**[[1dod]], [[1doe]], [[1iuv]], [[1iuw]], [[1iux]] – PaPHBH + FAD + DHB derivative<br />
**[[1ius]], [[1iut]], [[1iuu]] – PaPHBH + FAD + 4-aminobenzoate <br />
**[[1ius]], [[1iut]], [[1iuu]] – PaPHBH + FAD + 4-aminobenzoate <br />
 +
**[[8y2s]] – PaPHBH + FAD + hydroxy-methylbenzoate <br />
**[[6ju1]] – PaPHBH (mutant) + FAD + DHB derivative <br />
**[[6ju1]] – PaPHBH (mutant) + FAD + DHB derivative <br />
**[[1d7l]] – PaPHBH + FAD derivative + PHB <br />
**[[1d7l]] – PaPHBH + FAD derivative + PHB <br />
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**[[2dki]] – CtPHBH + FAD – ''Comamonas testosteroni''<br />
**[[2dki]] – CtPHBH + FAD – ''Comamonas testosteroni''<br />
**[[2dkh]] – CtPHBH + FAD + hydroxy-benzoate <br />
**[[2dkh]] – CtPHBH + FAD + hydroxy-benzoate <br />
 +
**[[8r2t]] – PHBH + FAD – ''Gelatoporia subvermipora''<br />
*Apartyl/asparaginyl b-hydroxylase; Domain – oxygenase and TPR 301-758
*Apartyl/asparaginyl b-hydroxylase; Domain – oxygenase and TPR 301-758
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**[[5jza]] – hAAH oxygenase and TPR domain + oxalylglycine + Mn <br />
**[[5jza]] – hAAH oxygenase and TPR domain + oxalylglycine + Mn <br />
**[[6yyu]], [[6yyv]] – hAAH oxygenase and TPR domain + oxoglutarate + Mn <br />
**[[6yyu]], [[6yyv]] – hAAH oxygenase and TPR domain + oxoglutarate + Mn <br />
-
**[[6yyw]], [[6yyx]], [[6yyy]], [[6z6q]] – hAAH oxygenase and TPR domain + oxoglutarate + Mn + coagulation factor X peptide<br />
+
**[[6yyw]], [[6yyx]], [[6yyy]], [[6z6q]], [[8re8]], [[8re9]] – hAAH oxygenase and TPR domain + oxoglutarate + Mn + coagulation factor X peptide<br />
-
**[[5jz8]], [[5jzu]], [[6rk9]], [[5jqy]], [[6z6r]] – hAAH oxygenase and TPR domain + oxalyl derivative + Mn + coagulation factor X peptide<br />
+
**[[8re6]], [[8re7]] – hAAH oxygenase and TPR domain (mutant) + oxoglutarate + Mn + coagulation factor X peptide<br />
 +
**[[5jqy]], [[5jz8]], [[5jzu]], [[5jzz]], [[6rk9]], [[6z6r]], [[8re5]] – hAAH oxygenase and TPR domain + oxalyl derivative + Mn + coagulation factor X peptide<br />
**[[7e6j]] – hAAH oxygenase and TPR domain (mutant) + coagulation factor X peptide<br />
**[[7e6j]] – hAAH oxygenase and TPR domain (mutant) + coagulation factor X peptide<br />
**[[6q9f]], [[6q9i]] – hAAH oxygenase and TPR domain (mutant) + oxalylglycine + Mn + coagulation factor X peptide<br />
**[[6q9f]], [[6q9i]] – hAAH oxygenase and TPR domain (mutant) + oxalylglycine + Mn + coagulation factor X peptide<br />
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**[[6dax]], [[6alm]], [[6aln]], [[6mp8]] – SvAAH + arginine + oxoglutarate + Fe – ''Streptomyces vinaceus''<br />
**[[6dax]], [[6alm]], [[6aln]], [[6mp8]] – SvAAH + arginine + oxoglutarate + Fe – ''Streptomyces vinaceus''<br />
**[[6daz]], [[6alo]], [[6alp]], [[6alq]], [[6y12]] – SvAAH + arginine + succinate + Fe <br />
**[[6daz]], [[6alo]], [[6alp]], [[6alq]], [[6y12]] – SvAAH + arginine + succinate + Fe <br />
 +
**[[9eqf]] – AAH + arginine + succinate + Fe - synthetic<br />
**[[6y0n]] – SvAAH + arginine + AKG + Fe <br />
**[[6y0n]] – SvAAH + arginine + AKG + Fe <br />
**[[6db2]], [[6alr]] – SvAAH + homoarginine + succinate + V <br />
**[[6db2]], [[6alr]] – SvAAH + homoarginine + succinate + V <br />
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**[[2wbp]] – SvVIOC + Fe + succinate + Arg derivative<br />
**[[2wbp]] – SvVIOC + Fe + succinate + Arg derivative<br />
**[[6daw]] – NAPI + Fe + Arg – ''Streptomyces lusitanus''<br />
**[[6daw]] – NAPI + Fe + Arg – ''Streptomyces lusitanus''<br />
 +
 +
*Prolyl 3-hydroxylase
 +
 +
**[[8k0e]] - hPH 1 + cartilage-associated protein – Cryo EM<br />
 +
**[[8k0f]], [[8k0i]], [[8k0m]] - hPH 1 + cartilage-associated protein + PPIASE – Cryo EM<br />
 +
**[[8k17]] - hPH 1 + cartilage-associated protein + PPIASE + peptide – Cryo EM<br />
*Prolyl 4-hydroxylase
*Prolyl 4-hydroxylase
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**[[6ttm]], [[6ttn]] - dHH + Ni + oxalylglycine + hyoscyamine – datura<br />
**[[6ttm]], [[6ttn]] - dHH + Ni + oxalylglycine + hyoscyamine – datura<br />
**[[6tto]] - dHH + Ni + oxoglutaratee <br />
**[[6tto]] - dHH + Ni + oxoglutaratee <br />
 +
**[[8cv8]], [[8cvb]] - dHH + Fe + oxoglutarate + hyoscyamine <br />
 +
**[[8cve]], [[8cvg]] - dHH (mutant) + Fe + oxoglutarate + hyoscyamine <br />
 +
**[[8cva]] - dHH + Fe + succinate + hyoscyamine <br />
 +
**[[8cv9]], [[8cvc]] - dHH + V + succinate + hyoscyamine <br />
 +
**[[8cvf]], [[8cvh]] - dHH (mutant) + V + succinate + hyoscyamine <br />
 +
**[[8cvd]] - dHH + Fe + succinate + scopolamine <br />
*Cytochrome P450 hydroxylase See [[Cytochrome P450 hydroxylase]]
*Cytochrome P450 hydroxylase See [[Cytochrome P450 hydroxylase]]

Current revision

3D structures of hydroxylases

Updated on 17-September-2025

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

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