1wmh

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[[Image:1wmh.jpg|left|200px]]
[[Image:1wmh.jpg|left|200px]]
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{{Structure
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|PDB= 1wmh |SIZE=350|CAPTION= <scene name='initialview01'>1wmh</scene>, resolution 1.50&Aring;
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The line below this paragraph, containing "STRUCTURE_1wmh", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= PKCiota ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), Par6alpha ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=
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{{STRUCTURE_1wmh| PDB=1wmh | SCENE= }}
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|RELATEDENTRY=[[1vd2|1VD2]], [[1q1o|1Q1O]], [[1oey|1OEY]], [[1ipg|1IPG]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wmh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wmh OCA], [http://www.ebi.ac.uk/pdbsum/1wmh PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1wmh RCSB]</span>
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'''Crystal structure of a PB1 domain complex of Protein kinase c iota and Par6 alpha'''
'''Crystal structure of a PB1 domain complex of Protein kinase c iota and Par6 alpha'''
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[[Category: Takeya, R.]]
[[Category: Takeya, R.]]
[[Category: Yoshinaga, S.]]
[[Category: Yoshinaga, S.]]
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[[Category: apkc]]
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[[Category: Apkc]]
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[[Category: cell polarity]]
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[[Category: Cell polarity]]
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[[Category: kinase]]
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[[Category: Kinase]]
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[[Category: opca motif]]
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[[Category: Opca motif]]
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[[Category: par6]]
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[[Category: Par6]]
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[[Category: pb1 domain]]
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[[Category: Pb1 domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:52:33 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:38:18 2008''
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Revision as of 10:52, 3 May 2008

Image:1wmh.jpg

Template:STRUCTURE 1wmh

Crystal structure of a PB1 domain complex of Protein kinase c iota and Par6 alpha


Overview

A complex of atypical PKC and Par6 is a common regulator for cell polarity-related processes, which is an essential clue to evolutionary conserved cell polarity regulation. Here, we determined the crystal structure of the complex of PKCiota and Par6alpha PB1 domains to a resolution of 1.5 A. Both PB1 domains adopt a ubiquitin fold. PKCiota PB1 presents an OPR, PC, and AID (OPCA) motif, 28 amino acid residues with acidic and hydrophobic residues, which interacts with the conserved lysine residue of Par6alpha PB1 in a front and back manner. On the interface, several salt bridges are formed including the conserved acidic residues on the OPCA motif of PKCiota PB1 and the conserved lysine residue on the Par6alpha PB1. Structural comparison of the PKCiota and Par6alpha PB1 complex with the p40phox and p67phox PB1 domain complex, subunits of neutrophil NADPH oxidase, reveals that the specific interaction is achieved by tilting the interface so that the insertion or extension in the sequence is engaged in the specificity determinant. The PB1 domain develops the interaction surface on the ubiquitin fold to increase the versatility of molecular interaction.

About this Structure

1WMH is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of a cell polarity regulator, a complex between atypical PKC and Par6 PB1 domains., Hirano Y, Yoshinaga S, Takeya R, Suzuki NN, Horiuchi M, Kohjima M, Sumimoto H, Inagaki F, J Biol Chem. 2005 Mar 11;280(10):9653-61. Epub 2004 Dec 7. PMID:15590654 Page seeded by OCA on Sat May 3 13:52:33 2008

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