8ys3
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of rat thioredoxin, F54L mutant== | |
| - | + | <StructureSection load='8ys3' size='340' side='right'caption='[[8ys3]], [[Resolution|resolution]] 1.75Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8ys3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8YS3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8YS3 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.752Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ys3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ys3 OCA], [https://pdbe.org/8ys3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ys3 RCSB], [https://www.ebi.ac.uk/pdbsum/8ys3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ys3 ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/THIO_RAT THIO_RAT] Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity (By similarity). |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Takeshita | + | [[Category: Rattus norvegicus]] |
| - | [[Category: | + | [[Category: Baba T]] |
| + | [[Category: Kawasaki-Ohmori I]] | ||
| + | [[Category: Ohe C]] | ||
| + | [[Category: Ouchida M]] | ||
| + | [[Category: Saji S]] | ||
| + | [[Category: Takeshita K]] | ||
| + | [[Category: Yamamoto M]] | ||
| + | [[Category: Yamamoto S]] | ||
Current revision
Crystal structure of rat thioredoxin, F54L mutant
| |||||||||||
