9drj

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Current revision (05:46, 1 October 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9drj is ON HOLD until Paper Publication
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==Cryo-EM structure of a SUMO E1-E2-SUMO1 complex.==
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<StructureSection load='9drj' size='340' side='right'caption='[[9drj]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9drj]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9DRJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9DRJ FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9drj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9drj OCA], [https://pdbe.org/9drj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9drj RCSB], [https://www.ebi.ac.uk/pdbsum/9drj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9drj ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SAE1_HUMAN SAE1_HUMAN] The heterodimer acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.<ref>PMID:9920803</ref> <ref>PMID:10217437</ref> <ref>PMID:10187858</ref> <ref>PMID:11481243</ref> <ref>PMID:11451954</ref> <ref>PMID:15660128</ref> <ref>PMID:20164921</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Jia L]]
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[[Category: Nayak A]]
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[[Category: Nayak D]]
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[[Category: Olsen SK]]
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[[Category: Ruben EA]]
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[[Category: Wasmuth EV]]

Current revision

Cryo-EM structure of a SUMO E1-E2-SUMO1 complex.

PDB ID 9drj

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