9r4z
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Murine AA amyloid fibril morphology III (AA III)== | |
| + | <StructureSection load='9r4z' size='340' side='right'caption='[[9r4z]], [[Resolution|resolution]] 3.50Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[9r4z]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9R4Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9R4Z FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.5Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9r4z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9r4z OCA], [https://pdbe.org/9r4z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9r4z RCSB], [https://www.ebi.ac.uk/pdbsum/9r4z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9r4z ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/SAA2_MOUSE SAA2_MOUSE] Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/SAA2_MOUSE SAA2_MOUSE] Major acute phase reactant. Apolipoprotein of the HDL complex. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The co-deposition of amyloid fibrils from different precursor proteins is a topic of increasing relevance for protein misfolding diseases. Using cryo-electron microscopy (cryo-EM), we here determined the structures of two serum amyloid A (SAA) protein-derived amyloid fibril morphologies that were extracted from a mouse strain that is primarily known to be associated with apolipoprotein A-II-derived amyloid fibrils. The two fibril morphologies show the same protomer conformation as in previously reported ex vivo amyloid fibrils from SAA protein but a different relative arrangement of fibril protein stacks. These data establish that serum amyloid A-derived amyloid fibrils share the same fibril protein fold in different mouse strains and disease contexts. | ||
| - | + | Cryo-EM Observation of AA Amyloid Fibrils in Mouse Model of Systemic AApoAII Amyloidosis.,Andreotti G, Higuchi K, Schmidt M, Fandrich M J Mol Biol. 2025 Sep 11;437(24):169438. doi: 10.1016/j.jmb.2025.169438. PMID:40945578<ref>PMID:40945578</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 9r4z" style="background-color:#fffaf0;"></div> |
| - | [[Category: Andreotti | + | == References == |
| - | [[Category: Schmidt | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Andreotti G]] | ||
| + | [[Category: Faendrich M]] | ||
| + | [[Category: Schmidt M]] | ||
Current revision
Murine AA amyloid fibril morphology III (AA III)
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