Interleukin receptor 3D structures

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Current revision (07:36, 5 October 2025) (edit) (undo)
 
Line 15: Line 15:
**[[1z92]] – hIL2R α subunit + IL2<br />
**[[1z92]] – hIL2R α subunit + IL2<br />
-
**[[5m5e]] - hIL2R β subunit + IL2 + cytokine receptor common subunit γ<br />
+
**[[3iu3]], [[3nfp]] - hIL2R α subunit + antibody
 +
**[[5m5e]] - hIL2R β + gamma subunits + IL2 <br />
**[[2b5i]] - hIL2R α+β+γ subunits + IL2<br />
**[[2b5i]] - hIL2R α+β+γ subunits + IL2<br />
**[[3qaz]], [[6dg5]] - hIL2R β+γ subunits + IL2<br />
**[[3qaz]], [[6dg5]] - hIL2R β+γ subunits + IL2<br />
**[[2erj]] - hIL2R α (mutant)+β+γ (mutant) subunits + IL2 (mutant)<br />
**[[2erj]] - hIL2R α (mutant)+β+γ (mutant) subunits + IL2 (mutant)<br />
**[[3qb7]] - hIL2R γ (mutant) subunit + IL2<br />
**[[3qb7]] - hIL2R γ (mutant) subunit + IL2<br />
-
**[[8epa]] - hIL2R γ subunit + antibody – Cryo EM<br />
+
**[[8epa]], [[9jqt]] - hIL2R γ subunit + antibody – Cryo EM<br />
-
**[[3iu3]], [[3nfp]] - hIL2R α subunit + antibody
+
*Interleukin-3 receptor
*Interleukin-3 receptor
Line 27: Line 27:
**[[4jzj]] – hIL3R α subunit + antibody<br />
**[[4jzj]] – hIL3R α subunit + antibody<br />
**[[5uv8]], [[5uwc]] – hIL3R α subunit (mutant) + IL3<br />
**[[5uv8]], [[5uwc]] – hIL3R α subunit (mutant) + IL3<br />
-
**[[6nmy]] – hIL3R α subunit (mutant) + IL3 + cytokine receptor common subunit b<br />
+
**[[6nmy]] – hIL3R α subunit (mutant) + beta subunit + IL3 + cytokine receptor common subunit b<br />
**[[4qqv]] - mIL6R β subunit (mutant) - mouse<br />
**[[4qqv]] - mIL6R β subunit (mutant) - mouse<br />
Line 36: Line 36:
**[[3bpn]] - hIL4R α subunit + hIL13R α subunit + IL4<br />
**[[3bpn]] - hIL4R α subunit + hIL13R α subunit + IL4<br />
**[[3bpo]] - hIL4R α subunit + hIL13R α subunit + IL13<br />
**[[3bpo]] - hIL4R α subunit + hIL13R α subunit + IL13<br />
-
**[[6oel]] - hIL4R α subunit + hIL2R γ subunit + IL4 + antibody<br />
+
**[[8k4q]], [[8z8l]] - hIL4R α subunit + nanobody<br />
 +
**[[6oel]] - hIL4R α subunit + hIL2R gamma subunit + IL4 + antibody<br />
*Interleukin-5 receptor
*Interleukin-5 receptor
Line 43: Line 44:
**[[3va2]] - hIL5R α subunit + IL5<br />
**[[3va2]] - hIL5R α subunit + IL5<br />
**[[6h41]] - hIL5R α subunit + peptide ihibitor<br />
**[[6h41]] - hIL5R α subunit + peptide ihibitor<br />
 +
**[[8tld]] - hIL5R α + beta subunits + IL5 – Cryo EM <BR />
*Interleukin-6 receptor or gp130
*Interleukin-6 receptor or gp130
Line 52: Line 54:
**[[2arw]] - hIL6R α subunit - NMR<br />
**[[2arw]] - hIL6R α subunit - NMR<br />
**[[1p9m]] - hIL6R α + β subunits + IL6<br />
**[[1p9m]] - hIL6R α + β subunits + IL6<br />
 +
**[[8upa]] – hIL6R β 124-321 + sIL-6 1-56 – synthetic<br />
**[[7dc8]] – hIL6R α subunit + antibody<br />
**[[7dc8]] – hIL6R α subunit + antibody<br />
 +
**[[8iow]], [[8j6f]] – hIL6R α subunit + antibody – Cryo EM<br />
 +
**[[8d7r]] – hIL6R beta subunit in CLCF1 complex – Cryo EM<br />
 +
**[[8d74]] – hIL6R beta subunit in CNTF signaling complex – Cryo EM<br />
 +
**[[8v2b]], [[8v2c]] – hIL6R beta subunit + oncostatin + oncostatin-specific receptor beta subunit – Cryo EM<br />
 +
**[[8v2a]] – hIL6R beta subunit + oncostatin + LIFR - Cryo EM<br />
 +
**[[8d6a]] – hIL6R beta subunit + LIF + LIFR - Cryo EM<br />
**[[5fuc]] - mI6R α subunit + IL6 +VHH6<br />
**[[5fuc]] - mI6R α subunit + IL6 +VHH6<br />
**[[2hmh]] - mI6R β subunit + suppressor of cytokine signaling 3<br />
**[[2hmh]] - mI6R β subunit + suppressor of cytokine signaling 3<br />
Line 63: Line 72:
**[[6p50]], [[6p67]] - hIL7R α subunit + antibody<br />
**[[6p50]], [[6p67]] - hIL7R α subunit + antibody<br />
**[[4nn5]], [[4nn6]], [[4nn7]], [[5j12]], [[5j11]] - mIL7R α subunit + thymic stromal lymphopoietin + cytokine receptor-like factor 2<br />
**[[4nn5]], [[4nn6]], [[4nn7]], [[5j12]], [[5j11]] - mIL7R α subunit + thymic stromal lymphopoietin + cytokine receptor-like factor 2<br />
 +
**[[8ddc]] – mIL7R alpha subunit transmembrane domain + mIL2R gamma subunit transmembrane domain - NMR<br />
 +
 +
*Interleukin-9 receptor
 +
 +
**[[8ddd]] – mIL9R transmembrane domain + mIL2R gamma subunit transmembrane domain - NMR<br />
*Interleukin-10 receptor
*Interleukin-10 receptor
Line 71: Line 85:
**[[6o4p]] – hIL11R α subunit<br />
**[[6o4p]] – hIL11R α subunit<br />
 +
**[[8dpu]] - hIL11R alpha+beta + IL-11<br />
 +
**[[8dpt]] - hILR11 alpha (mutant) + hILR6 + hIL11– Cryo EM<br />
 +
 +
*Interleukin-12 receptor
 +
 +
**[[8c7m]], [[8odx]] - hIL13R beta1 subunit FN domains + antibody<br />
 +
**[[8pb1]], [[8yi7]] - hIL12R α and β + hIL12 α and β – Cryo EM<br />
 +
**[[8oe0]], [[8xrp]] - hIL12R beta1 and beta2 + hIL12 α and β – Cryo EM<br />
 +
**[[8oe4]] - hIL12R α and β + hIL12 α and β + hIL23R α and β + hIL23 α and β – Cryo EM<br />
*Interleukin-13 receptor
*Interleukin-13 receptor
Line 81: Line 104:
**[[2ers]] - hIL15R α subunit sushIL domain – NMR<br />
**[[2ers]] - hIL15R α subunit sushIL domain – NMR<br />
-
**[[2z3q]], [[2z3r]], [[2psm]] - hIL15R α subunit + IL15<br />
+
**[[2psm]], [[2z3q]], [[2z3r]] - hIL15R α subunit + IL15<br />
**[[4gs7]] - hIL15R α subunit + IL15 + hIL2R β,γ subunits<br />
**[[4gs7]] - hIL15R α subunit + IL15 + hIL2R β,γ subunits<br />
Line 105: Line 128:
**[[3tgx]] – hIL21R extracellular domain (mutant) + IL21<br />
**[[3tgx]] – hIL21R extracellular domain (mutant) + IL21<br />
**[[7kq7]] – hIL21R + antibody<br />
**[[7kq7]] – hIL21R + antibody<br />
 +
**[[9e2t]] - ILR21 + ILR2 gamma + hIL21 (mutant)<BR />
 +
**[[8ent]] - hIL21R (mutant) + IL2R gamma (mutant) + hIL21 (mutant) <BR />
*Interleukin-23 receptor
*Interleukin-23 receptor
**[[5mzv]] – hIL23R + IL12 + IL23 + nanobody<br />
**[[5mzv]] – hIL23R + IL12 + IL23 + nanobody<br />
 +
**[[9mfg]] – hIL23R + VHH<br />
 +
 +
*Interleukin-31 receptor
 +
 +
**[[9eza]] – hIL31R D1D2 domain + scFv<br />
*'''Interleukin receptor type II'''
*'''Interleukin receptor type II'''
Line 119: Line 149:
**[[3lqm]] - hIL10R β (mutant) subunit <br />
**[[3lqm]] - hIL10R β (mutant) subunit <br />
**[[6x93]] - hIL10R + IL10 – Cryo EM<br />
**[[6x93]] - hIL10R + IL10 – Cryo EM<br />
-
**[[5t5w]] - hIL10R (mutant) + interferon l receptor 1 + interferon l-3<br />
+
**[[5t5w]] - hIL10R (mutant) + interferon lambda receptor 1 + interferon lambda-3<br />
 +
**[[9bpu]], [[9bpv]] - hIL10R + interferon lambda receptor 1 + interferon lambda-3 – Cryo EM<br />
*Interleukin-20 receptor
*Interleukin-20 receptor

Current revision

3D structures of interleukin receptor

Updated on 05-October-2025

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel

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