Interleukin-1 receptor-associated kinase

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Current revision (07:40, 5 October 2025) (edit) (undo)
 
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**[[2nru]], [[2nry]], [[2oib]], [[2o8y]], [[4rmz]] – hIRAK4 kinase domain <br />
**[[2nru]], [[2nry]], [[2oib]], [[2o8y]], [[4rmz]] – hIRAK4 kinase domain <br />
 +
**[[8wtf]] - hIRAK4 164-460<br />
**[[4u97]], [[4u9a]] - hIRAK4 kinase domain (mutant)<br />
**[[4u97]], [[4u9a]] - hIRAK4 kinase domain (mutant)<br />
**[[2oic]], [[4xs2]] - hIRAK4 kinase domain + staurosporine<br />
**[[2oic]], [[4xs2]] - hIRAK4 kinase domain + staurosporine<br />
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**[[4y73]], [[4yo6]], [[4yp8]], [[4ztl]], [[4ztm]], [[4ztn]], [[5kx7]], [[5kx8]], [[5t1s]], [[5t1t]], [[5uiq]], [[5uir]], [[5uis]], [[5uit]], [[5uiu]], [[6f3d]], [[6f3e]], [[6f3g]], [[6f3i]], [[6lxy]], [[6n8g]], [[6o8u]], [[6o94]], [[6o95]], [[6o9d]], [[6thw]], [[6thx]], [[6thz]], [[6ti8]], [[6tia]], [[6uya]], [[6vql]], [[7c2v]], [[7c2w]], [[7og1]], [[7qg2]], [[7qg3]], [[7qg5]], [[8dks]] - hIRAK4 kinase domain + inhibitor<br />,
+
**[[4y73]], [[4yo6]], [[4yp8]], [[4ztl]], [[4ztm]], [[4ztn]], [[5kx7]], [[5kx8]], [[5t1s]], [[5t1t]], [[5uiq]], [[5uir]], [[5uis]], [[5uit]], [[5uiu]], [[6f3d]], [[6f3e]], [[6f3g]], [[6f3i]], [[6lxy]], [[6n8g]], [[6o8u]], [[6o94]], [[6o95]], [[6o9d]], [[6thw]], [[6thx]], [[6thz]], [[6ti8]], [[6tia]], [[6uya]], [[6vql]], [[7c2v]], [[7c2w]], [[7og1]], [[7qg2]], [[7qg3]], [[7qg5]], [[8atb]], [[8br5]], [[8br6]], [[8br7]], [[8dks]], [[8sce]], [[8scv]], [[8scw]], [[8tvm]], [[8tvn]], [[8tx0]], [[8ucb]], [[8ucc]], [[8v1o]], [[8v2f]], [[8v2l]], [[8w3w]], [[8w3x]], [[9na2]], [[9na3]], [[9na4]], [[9na5]], [[9na6]] - hIRAK4 kinase domain + inhibitor<br />
**[[5w84]], [[5w85]], [[5k72]], [[5k75]], [[5k76]], [[5k7g]], [[5k7i]], [[6ega]], [[6eg9]], [[6egd]], [[6ege]], [[6egf]], [[6mom]], [[6rfi]], [[6rfj]] - hIRAK4 residues 154-460 + inhibitor<br />
**[[5w84]], [[5w85]], [[5k72]], [[5k75]], [[5k76]], [[5k7g]], [[5k7i]], [[6ega]], [[6eg9]], [[6egd]], [[6ege]], [[6egf]], [[6mom]], [[6rfi]], [[6rfj]] - hIRAK4 residues 154-460 + inhibitor<br />
**[[2oid]] - hIRAK4 kinase domain + AMPPNP<br />
**[[2oid]] - hIRAK4 kinase domain + AMPPNP<br />

Current revision

Mouse IRAK4 death domain complex with Mn+2 ion , 2a9i

Drag the structure with the mouse to rotate

3D structures of interleukin-1 receptor-associated kinase

Updated on 05-October-2025

References

  1. ↑ Cao Z, Henzel WJ, Gao X. IRAK: a kinase associated with the interleukin-1 receptor. Science. 1996 Feb 23;271(5252):1128-31. PMID:8599092
  2. ↑ Singer JW, Fleischman A, Al-Fayoumi S, Mascarenhas JO, Yu Q, Agarwal A. Inhibition of interleukin-1 receptor-associated kinase 1 (IRAK1) as a therapeutic strategy. Oncotarget. 2018 Sep 7;9(70):33416-33439. PMID:30279971 doi:10.18632/oncotarget.26058
  3. ↑ Benosman S, Ravanan P, Correa RG, Hou YC, Yu M, Gulen MF, Li X, Thomas J, Cuddy M, Matsuzawa Y, Sano R, Diaz P, Matsuzawa S, Reed JC. Interleukin-1 receptor-associated kinase-2 (IRAK2) is a critical mediator of endoplasmic reticulum (ER) stress signaling. PLoS One. 2013 May 28;8(5):e64256. PMID:23724040 doi:10.1371/journal.pone.0064256
  4. ↑ Nguyen TH, Turek I, Meehan-Andrews T, Zacharias A, Irving H. Analysis of interleukin-1 receptor associated kinase-3 (IRAK3) function in modulating expression of inflammatory markers in cell culture models: A systematic review and meta-analysis. PLoS One. 2020 Dec 31;15(12):e0244570. PMID:33382782 doi:10.1371/journal.pone.0244570
  5. ↑ De Nardo D, Balka KR, Cardona Gloria Y, Rao VR, Latz E, Masters SL. Interleukin-1 receptor-associated kinase 4 (IRAK4) plays a dual role in myddosome formation and Toll-like receptor signaling. J Biol Chem. 2018 Sep 28;293(39):15195-15207. PMID:30076215 doi:10.1074/jbc.RA118.003314

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