Intersectin

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Current revision (08:32, 5 October 2025) (edit) (undo)
 
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*Intersectin 1 long isoform
*Intersectin 1 long isoform
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**[[1ki1]] - hITSN1 DBL+PH domains 1229-1580 + Cdc42<br />
+
**[[5hzj]] - hITSN1 DBL+PH domains 1229-1580 <br />
 +
**[[5hzi]] - hITSN1 DBL+PH domains (mutant)<br />
 +
**[[1ki1]], [[5hzk]] - hITSN1 DBL+PH domains + Cdc42<br />
**[[3qbv]] - hITSN1 DBL+PH domains (mutant) + Cdc42<br />
**[[3qbv]] - hITSN1 DBL+PH domains (mutant) + Cdc42<br />
**[[3jv3]] - mITSN1 5th SH3+DH domains 1151-1431 <br />
**[[3jv3]] - mITSN1 5th SH3+DH domains 1151-1431 <br />

Current revision

Human intersectin 1 short isoform 4th SH3 domain (green, yellow, cyan, purple) complex with FCSHD2 SH3 2nd domain (deepskyblue, pink, light pink, orange) (PDB code 6gbu)

Drag the structure with the mouse to rotate

3D structures of intersectin

Updated on 05-October-2025

References

  1. ↑ . Correction for Gerth et al., Intersectin associates with synapsin and regulates its nanoscale localization and function. Proc Natl Acad Sci U S A. 2017 Dec 19;114(51):E11060. doi:, 10.1073/pnas.1720226115. Epub 2017 Dec 11. PMID:29229830 doi:http://dx.doi.org/10.1073/pnas.1720226115
  2. ↑ Malakooti N, Pritchard MA, Chen F, Yu Y, Sgambelloni C, Adlard PA, Finkelstein DI. The Long Isoform of Intersectin-1 Has a Role in Learning and Memory. Front Behav Neurosci. 2020 Feb 25;14:24. PMID:32161523 doi:10.3389/fnbeh.2020.00024
  3. ↑ Pucharcos C, Estivill X, de la Luna S. Intersectin 2, a new multimodular protein involved in clathrin-mediated endocytosis. FEBS Lett. 2000 Jul 28;478(1-2):43-51. doi: 10.1016/s0014-5793(00)01793-2. PMID:10922467 doi:http://dx.doi.org/10.1016/s0014-5793(00)01793-2
  4. ↑ Russo A, O'Bryan JP. Intersectin 1 is required for neuroblastoma tumorigenesis. Oncogene. 2012 Nov 15;31(46):4828-34. doi: 10.1038/onc.2011.643. Epub 2012 Jan, 23. PMID:22266851 doi:http://dx.doi.org/10.1038/onc.2011.643
  5. ↑ Li J, Bu X, Chen X, Xiong P, Chen Z, Yu L. Predictive value of long non-coding RNA intersectin 1-2 for occurrence and in-hospital mortality of severe acute pancreatitis. J Clin Lab Anal. 2019 Dec 27:e23170. doi: 10.1002/jcla.23170. PMID:31880027 doi:http://dx.doi.org/10.1002/jcla.23170
  6. ↑ Hunter MP, Nelson M, Kurzer M, Wang X, Kryscio RJ, Head E, Pinna G, O'Bryan JP. Intersectin 1 contributes to phenotypes in vivo: implications for Down's syndrome. Neuroreport. 2011 Oct 26;22(15):767-72. doi: 10.1097/WNR.0b013e32834ae348. PMID:21876463 doi:http://dx.doi.org/10.1097/WNR.0b013e32834ae348
  7. ↑ Almeida-Souza L, Frank RAW, Garcia-Nafria J, Colussi A, Gunawardana N, Johnson CM, Yu M, Howard G, Andrews B, Vallis Y, McMahon HT. A Flat BAR Protein Promotes Actin Polymerization at the Base of Clathrin-Coated Pits. Cell. 2018 Jun 4. pii: S0092-8674(18)30597-X. doi: 10.1016/j.cell.2018.05.020. PMID:29887380 doi:http://dx.doi.org/10.1016/j.cell.2018.05.020

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Michal Harel, Alexander Berchansky

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