1wp9

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[[Image:1wp9.gif|left|200px]]
[[Image:1wp9.gif|left|200px]]
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{{Structure
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|PDB= 1wp9 |SIZE=350|CAPTION= <scene name='initialview01'>1wp9</scene>, resolution 2.9&Aring;
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The line below this paragraph, containing "STRUCTURE_1wp9", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosinetriphosphatase Adenosinetriphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.3 3.6.1.3] </span>
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{{STRUCTURE_1wp9| PDB=1wp9 | SCENE= }}
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|RELATEDENTRY=[[1j22|1j22]], [[1j23|1j23]], [[1j24|1j24]], [[1j25|1j25]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wp9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wp9 OCA], [http://www.ebi.ac.uk/pdbsum/1wp9 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1wp9 RCSB]</span>
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'''Crystal structure of Pyrococcus furiosus Hef helicase domain'''
'''Crystal structure of Pyrococcus furiosus Hef helicase domain'''
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[[Category: Nishino, T.]]
[[Category: Nishino, T.]]
[[Category: Tsuchiya, D.]]
[[Category: Tsuchiya, D.]]
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[[Category: atpase]]
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[[Category: Atpase]]
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[[Category: dna recombination]]
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[[Category: Dna recombination]]
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[[Category: dna repair]]
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[[Category: Dna repair]]
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[[Category: dna replication]]
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[[Category: Dna replication]]
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[[Category: helicase]]
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[[Category: Helicase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 13:58:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:39:18 2008''
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Revision as of 10:58, 3 May 2008

Image:1wp9.gif

Template:STRUCTURE 1wp9

Crystal structure of Pyrococcus furiosus Hef helicase domain


Overview

DNA and RNA frequently form various branched intermediates that are important for the transmission of genetic information. Helicases play pivotal roles in the processing of these transient intermediates during nucleic acid metabolism. The archaeal Hef helicase/ nuclease is a representative protein that processes flap- or fork-DNA structures, and, intriguingly, its C-terminal half belongs to the XPF/Mus81 nuclease family. Here, we report the crystal structure of the helicase domain of the Hef protein from Pyrococcus furiosus. The structure reveals a novel helical insertion between the two conserved helicase core domains. This positively charged extra region, structurally similar to the "thumb" domain of DNA polymerase, plays critical roles in fork recognition. The Hef helicase/nuclease exhibits sequence similarity to the Mph1 helicase from Saccharomyces cerevisiae; XPF/Rad1, involved in DNA repair; and a putative Hef homolog identified in mammals. Hence, our findings provide a structural basis for the functional mechanisms of this helicase/nuclease family.

About this Structure

1WP9 is a Single protein structure of sequence from Pyrococcus furiosus dsm 3638. Full crystallographic information is available from OCA.

Reference

Crystal structure and functional implications of Pyrococcus furiosus hef helicase domain involved in branched DNA processing., Nishino T, Komori K, Tsuchiya D, Ishino Y, Morikawa K, Structure. 2005 Jan;13(1):143-53. PMID:15642269 Page seeded by OCA on Sat May 3 13:58:30 2008

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