Isopenicillin N synthase
From Proteopedia
(Difference between revisions)
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
{{#tree:id=OrganizedByTopic|openlevels=0| | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
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| + | *IPNS | ||
| + | |||
| + | **[[8bbb]] - AnIPNS + ACV – ''Aspergillus nidulans''<br /> | ||
| + | **[[6jyv]] – IPNS – ''Pseudomonas aeruginosa''<br /> | ||
*Fe containing IPNS | *Fe containing IPNS | ||
| - | **[[1bk0]] - AnIPNS + ACV | + | **[[1bk0]], [[6y0o]], [[6zae]], [[6zaf]], [[6zag]], [[6zah]], [[6zam]] - AnIPNS + ACV + Fe <br /> |
| - | **[[2bjs]], [[7zoe]] - AnIPNS (mutant) + ACV<br /> | + | **[[2bjs]], [[7zoe]], [[8alj]], [[8bb9]], [[8bba]], [[8bbd]], [[8bsv]], [[8bsy]], [[8p47]], [[8ptv]] - AnIPNS (mutant) + ACV + Fe<br /> |
| - | **[[ | + | **[[1hb1]], [[1hb2]], [[1hb3]], [[1hb4]], [[1oc1]], [[1odm]], [[1odn]], [[1qiq]], [[1qjf]], [[1uzw]], [[1w03]], [[1w05]], [[1w3v]], [[1w3x]], [[2bu9]], [[2ivi]], [[2ivj]], [[2vau]], [[2vbb]], [[2vbd]], [[2vbp]], [[2vcm]], [[2ve1]], [[2wo7]], [[2y60]], [[2y6f]], [[4bb3]], [[8p7p]], [[8py5]] - AnIPNS + ACV derivative + Fe<br /> |
| - | **[[2jb4]] - AnIPNS + cyclobutanone analog<br /> | + | **[[8py8]], [[8py9]] - AnIPNS + ACV derivative + Fe + O2<br /> |
| - | **[[6y0p]], [[6zao]], [[6zaq]] - AnIPNS + IPN<br /> | + | **[[2jb4]] - AnIPNS + cyclobutanone analog + Fe<br /> |
| + | **[[6y0p]], [[6zao]], [[6zaq]], [[8py6]] - AnIPNS + IPN + Fe<br /> | ||
| + | **[[8p7o]] - AnIPNS + inhibitor + Fe<br /> | ||
| + | **[[7p3l]] - AnIPNS + substate analog + Fe<br /> | ||
| + | **[[8p46]] - AnIPNS (mutant) + IPN + Fe<br /> | ||
**[[1qje]] - AnIPNS + IPN + ACV<br /> | **[[1qje]] - AnIPNS + IPN + ACV<br /> | ||
| - | **[[6y0o]], [[6zae]], [[6zaf]], [[6zag]], [[6zah]], [[6zam]] - AnIPNS + ACV<br /> | ||
**[[6zai]], [[6zaj]], [[6zal]], [[6zap]] - AnIPNS + O2 + ACV<br /> | **[[6zai]], [[6zaj]], [[6zal]], [[6zap]] - AnIPNS + O2 + ACV<br /> | ||
**[[7poy]] - AnIPNS (mutant) + NO + ACV<br /> | **[[7poy]] - AnIPNS (mutant) + NO + ACV<br /> | ||
| - | **[[7psw]] - AnIPNS (mutant) + Fe + ACV<br /> | + | **[[8py7]], [[8pya]] - AnIPNS (mutant) + Fe + O2 + ACV<br /> |
| + | **[[7psw]], [[8ali]], [[8bbc]], [[8bsw]], [[8bsx]], [[8p48]], [[8rdb]] - AnIPNS (mutant) + Fe + ACV<br /> | ||
**[[1blz]], [[6zan]] - AnIPNS + NO + ACV<br /> | **[[1blz]], [[6zan]] - AnIPNS + NO + ACV<br /> | ||
**[[1obn]], [[1w04]], [[1w06]] - AnIPNS + hydroxylamine + ACV derivative<br /> | **[[1obn]], [[1w04]], [[1w06]] - AnIPNS + hydroxylamine + ACV derivative<br /> | ||
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**[[1ips]] – AnIPNS + Mn<br /> | **[[1ips]] – AnIPNS + Mn<br /> | ||
**[[6zw8]] - AnIPNS + ACV + Cd<br /> | **[[6zw8]] - AnIPNS + ACV + Cd<br /> | ||
| + | **[[8a4g]] - AnIPNS (mutant) + ACV + Cd<br /> | ||
| + | **[[6zAK]] - AnIPNS + ACV + VO2<br /> | ||
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}} | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category: Topic Page]] | [[Category: Topic Page]] | ||
Current revision
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3D structures of isopenicillin N synthase
Updated on 08-October-2025
References
- ↑ Burzlaff NI, Rutledge PJ, Clifton IJ, Hensgens CM, Pickford M, Adlington RM, Roach PL, Baldwin JE. The reaction cycle of isopenicillin N synthase observed by X-ray diffraction. Nature. 1999 Oct 14;401(6754):721-4. PMID:10537113 doi:10.1038/44400
- ↑ Roach PL, Clifton IJ, Hensgens CM, Shibata N, Schofield CJ, Hajdu J, Baldwin JE. Structure of isopenicillin N synthase complexed with substrate and the mechanism of penicillin formation. Nature. 1997 Jun 19;387(6635):827-30. PMID:9194566 doi:http://dx.doi.org/10.1038/42990
