9nmq

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Current revision (07:29, 8 October 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9nmq is ON HOLD until Paper Publication
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==Structure of mouse RyR1 with simvastatin (Ca2+/CFF/ATP dataset; closed pore)==
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<StructureSection load='9nmq' size='340' side='right'caption='[[9nmq]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9nmq]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9NMQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9NMQ FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1BYZ:[(1~{S},3~{R},7~{S},8~{S},8~{a}~{R})-3,7-dimethyl-8-[2-[(2~{R},4~{R})-4-oxidanyl-6-oxidanylidene-oxan-2-yl]ethyl]-1,2,3,7,8,8~{a}-hexahydronaphthalen-1-yl]+2,2-dimethylbutanoate'>A1BYZ</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CFF:CAFFEINE'>CFF</scene>, <scene name='pdbligand=PCW:1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PCW</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9nmq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9nmq OCA], [https://pdbe.org/9nmq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9nmq RCSB], [https://www.ebi.ac.uk/pdbsum/9nmq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9nmq ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RYR1_MOUSE RYR1_MOUSE] Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytosol and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules (PubMed:18003898, PubMed:21156754, PubMed:7515481, PubMed:7621815). Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm (PubMed:18268335). Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain (PubMed:22036948). Required for normal embryonic development of muscle fibers and skeletal muscle (PubMed:7515481). Required for normal heart morphogenesis, skin development and ossification during embryogenesis (PubMed:18003898, PubMed:7515481).<ref>PMID:18003898</ref> <ref>PMID:18268335</ref> <ref>PMID:21156754</ref> <ref>PMID:22036948</ref> <ref>PMID:7515481</ref> <ref>PMID:7621815</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: Marks AR]]
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[[Category: Weninger G]]

Current revision

Structure of mouse RyR1 with simvastatin (Ca2+/CFF/ATP dataset; closed pore)

PDB ID 9nmq

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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