9qbo
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Yeast 20S proteasome mutant: beta5_G128V (b5-propeptide in trans) in complex with MG132== | |
| - | + | <StructureSection load='9qbo' size='340' side='right'caption='[[9qbo]], [[Resolution|resolution]] 2.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9qbo]] is a 24 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9QBO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9QBO FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1I48:(2~{S},3~{R})-2-azanyl-3-[(1~{R},2~{S})-2-azanyl-4-methyl-1-oxidanyl-pentoxy]butanoic+acid'>A1I48</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=P6S:(phenylmethyl)+hydrogen+carbonate'>P6S</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9qbo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9qbo OCA], [https://pdbe.org/9qbo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9qbo RCSB], [https://www.ebi.ac.uk/pdbsum/9qbo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9qbo ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: Heinemeyer | + | == Function == |
| + | [https://www.uniprot.org/uniprot/PSA2_YEAST PSA2_YEAST] The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Saccharomyces cerevisiae]] | ||
| + | [[Category: Synthetic construct]] | ||
| + | [[Category: Groll M]] | ||
| + | [[Category: Heinemeyer W]] | ||
| + | [[Category: Huber EM]] | ||
Revision as of 07:33, 8 October 2025
Yeast 20S proteasome mutant: beta5_G128V (b5-propeptide in trans) in complex with MG132
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