User:Wayne Decatur/mof dev
From Proteopedia
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| + | <StructureSection load='1d66' size='500' frame='true' side='right' caption='A Metal–organic framework structure: the CSD entry JARMEU' scene='10/1092924/Jarmeu_basics/1' > | ||
A cubic diamond lattice metal-organic framework | A cubic diamond lattice metal-organic framework | ||
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<!-- important to note you need to use 'side' in a StructureSection instead of 'align'. If you leave 'align' it doesn't work.--> | <!-- important to note you need to use 'side' in a StructureSection instead of 'align'. If you leave 'align' it doesn't work.--> | ||
==Background== | ==Background== | ||
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==A cubic diamond lattice metal-organic framework== | ==A cubic diamond lattice metal-organic framework== | ||
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| + | Shown at the right is the building block of the lattice (<scene name='10/1092924/Jarmeu_basics/1'>restore initial scene</scene>). | ||
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| + | <span style="font-size:200%;">{{Template:ColorKey_Element_C}}, {{Template:ColorKey_Element_N}}, '''<span style="background-color:black;color:yellow;"> S </span>, {{Font color|#00b000|Pd}}'''</span> | ||
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<jmol> | <jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
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</jmolCheckbox> | </jmolCheckbox> | ||
</jmol> | </jmol> | ||
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| - | <!--<scene name='70/701975/1d66_firstglance_secondary/2'>Each monomer</scene> of the protein dimer has 3 '''<font color='#f00080'> alpha helices</font>'''. | ||
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| - | The protein <scene name='70/701975/1d66_firstglance/2'>binds as a dimer to a symmetrical 17-base-pair sequence</scene>. Specifically, the consensus Gal4p-binding site is a 17-mer of sequence conforming to the motif below, which has the key feature of CGG triplets at the 5' ends, separated by 11 bps, or 5′-CGG-N11-CCG-3′.<br> | ||
| - | <br>--> | ||
| - | <!--<span style="font-weight: bold;font-family: Courier New; font-size: 14pt">--> | ||
| - | <!-- By setting font to courier, I can use non-proportional font. Whereas by default, rest of Proteopedia is proportional | ||
| - | <span style="background:black;color:#FFC0C8">5'-CGGNNNNNNNNNNNCCG-3'</span><br> | ||
| - | <font style='background:black;color:#ffffff;'>|||||||||||||||||</font><br> | ||
| - | <span style="background:black;color:#FFFF80">3'-CGGNNNNNNNNNNNGGC-5'</span></span>--> | ||
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| - | Shown at the right is the building block of the lattice (<scene name='10/1092924/Jarmeu_basics/1'>restore initial scene</scene>). | ||
When the repeats of this building block are shown connected to others, the lattice appears. Viewing the <scene name='10/1092924/Csd_entry_jarmeu_1x1x3_set/3'>the CSD entry JARMEU as a 1x1x3 set of the metal organic framework</scene> illustrates this.<br/> | When the repeats of this building block are shown connected to others, the lattice appears. Viewing the <scene name='10/1092924/Csd_entry_jarmeu_1x1x3_set/3'>the CSD entry JARMEU as a 1x1x3 set of the metal organic framework</scene> illustrates this.<br/> | ||
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The large cavities are visible as the lattice layers onto itself as the view of the structure rotates. <br/> | The large cavities are visible as the lattice layers onto itself as the view of the structure rotates. <br/> | ||
| - | The extensive nature becomes more apparent if we consider more of the | + | The extensive nature of the lattice with the large catvities becomes more apparent if we consider more of the repeated building blocks. <br/> |
<scene name='10/1092924/Csd_entry_jarmeu_1x3x3_plane/2'>The CSD entry JARMEU as a 1x3x3 plane of the metal organic framework</scene>. (Substatntial patience required when loading this scene; it is suggested to only do that after you have examined the others.) | <scene name='10/1092924/Csd_entry_jarmeu_1x3x3_plane/2'>The CSD entry JARMEU as a 1x3x3 plane of the metal organic framework</scene>. (Substatntial patience required when loading this scene; it is suggested to only do that after you have examined the others.) | ||
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==Significance== | ==Significance== | ||
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safety, and drug delivery & diagnostics/therapy have been demonstrated<ref>https://www.nobelprize.org/uploads/2025/10/advanced-chemistryprize2025.pdf</ref>. | safety, and drug delivery & diagnostics/therapy have been demonstrated<ref>https://www.nobelprize.org/uploads/2025/10/advanced-chemistryprize2025.pdf</ref>. | ||
| + | Highlighting the significance is the fact [[Proteopedia:Hot_News| three chemists doing seminal work in this field were awarded the Nobel Prize in Chemistry in 2025]]. The beautiful structure featured here played a key role in establishing this field. | ||
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| + | </StructureSection> | ||
==Technical Details== | ==Technical Details== | ||
Revision as of 19:10, 9 October 2025
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Contents |
Technical Details
The views featuring the 1x1x3 set and the plane were built using the Jmol Crystal Symmetry Explorer to examine CSD Entry: JARMEU.
Reference
- B.F. Hoskins and R. Robson. 1989. Infinite polymeric frameworks consisting of three dimensionally linked rod-like segments. Journal of the American Chemical Society, v111, pg. 5962-5964, |DOI: 10.1021/ja00197a079
See also
A catalytic molybdenum metal-organic framework
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Technical Details
The views featuring the 1x1x3 set and the plane were built using the Jmol Crystal Symmetry Explorer to examine CSD Entry: WUTXUH.
Reference
- Xia Z, Li F, Xu L, Feng P. A stable and highly selective metalloporphyrin based framework for the catalytic oxidation of cyclohexene. Dalton Trans. 2020 Aug 18;49(32):11157-11162. PMID:32744270 doi:10.1039/d0dt01420f
