1wqy

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[[Image:1wqy.gif|left|200px]]
[[Image:1wqy.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1wqy |SIZE=350|CAPTION= <scene name='initialview01'>1wqy</scene>, resolution 2.00&Aring;
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The line below this paragraph, containing "STRUCTURE_1wqy", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DOD:DEUTERATED+WATER'>DOD</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1wqy| PDB=1wqy | SCENE= }}
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|RELATEDENTRY=[[167d|167D]], [[1wqz|1WQZ]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wqy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wqy OCA], [http://www.ebi.ac.uk/pdbsum/1wqy PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1wqy RCSB]</span>
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}}
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'''X-RAY structural analysis of B-DNA decamer D(CCATTAATGG)2 crystal grown in D2O solution'''
'''X-RAY structural analysis of B-DNA decamer D(CCATTAATGG)2 crystal grown in D2O solution'''
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==About this Structure==
==About this Structure==
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1WQY is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WQY OCA].
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WQY OCA].
==Reference==
==Reference==
Complicated water orientations in the minor groove of the B-DNA decamer d(CCATTAATGG)2 observed by neutron diffraction measurements., Arai S, Chatake T, Ohhara T, Kurihara K, Tanaka I, Suzuki N, Fujimoto Z, Mizuno H, Niimura N, Nucleic Acids Res. 2005 May 24;33(9):3017-24. Print 2005. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15914673 15914673]
Complicated water orientations in the minor groove of the B-DNA decamer d(CCATTAATGG)2 observed by neutron diffraction measurements., Arai S, Chatake T, Ohhara T, Kurihara K, Tanaka I, Suzuki N, Fujimoto Z, Mizuno H, Niimura N, Nucleic Acids Res. 2005 May 24;33(9):3017-24. Print 2005. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15914673 15914673]
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[[Category: Protein complex]]
 
[[Category: Arai, S.]]
[[Category: Arai, S.]]
[[Category: Chatake, T.]]
[[Category: Chatake, T.]]
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[[Category: Suzuki, N.]]
[[Category: Suzuki, N.]]
[[Category: Tanaka, I.]]
[[Category: Tanaka, I.]]
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[[Category: b-dna]]
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[[Category: B-dna]]
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[[Category: hydration]]
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[[Category: Hydration]]
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[[Category: hydrogen]]
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[[Category: Hydrogen]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:01:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:39:53 2008''
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Revision as of 11:01, 3 May 2008

Image:1wqy.gif

Template:STRUCTURE 1wqy

X-RAY structural analysis of B-DNA decamer D(CCATTAATGG)2 crystal grown in D2O solution


Overview

It has long been suspected that the structure and function of a DNA duplex can be strongly dependent on its degree of hydration. By neutron diffraction experiments, we have succeeded in determining most of the hydrogen (H) and deuterium (D) atomic positions in the decameric d(CCATTAATGG)2 duplex. Moreover, the D positions in 27 D2O molecules have been determined. In particular, the complex water network in the minor groove has been observed in detail. By a combined structural analysis using 2.0 A resolution X-ray and 3.0 A resolution neutron data, it is clear that the spine of hydration is built up, not only by a simple hexagonal hydration pattern (as reported in earlier X-ray studies), but also by many other water bridges hydrogen-bonded to the DNA strands. The complexity of the hydration pattern in the minor groove is derived from an extraordinary variety of orientations displayed by the water molecules.

About this Structure

Full crystallographic information is available from OCA.

Reference

Complicated water orientations in the minor groove of the B-DNA decamer d(CCATTAATGG)2 observed by neutron diffraction measurements., Arai S, Chatake T, Ohhara T, Kurihara K, Tanaka I, Suzuki N, Fujimoto Z, Mizuno H, Niimura N, Nucleic Acids Res. 2005 May 24;33(9):3017-24. Print 2005. PMID:15914673 Page seeded by OCA on Sat May 3 14:01:49 2008

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