9gzv
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human NUDT14 in complex with a potent inhibitor (MA-955-9)== | |
| - | + | <StructureSection load='9gzv' size='340' side='right'caption='[[9gzv]], [[Resolution|resolution]] 1.95Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9gzv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9GZV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9GZV FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1IRF:1-(1-methylpiperidin-4-yl)-3-(3-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-4-amine'>A1IRF</scene>, <scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9gzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9gzv OCA], [https://pdbe.org/9gzv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9gzv RCSB], [https://www.ebi.ac.uk/pdbsum/9gzv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9gzv ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/NUD14_HUMAN NUD14_HUMAN] Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP. The physiological substrate is probably UDP-glucose. Poor activity on other substrates such as ADP-glucose, CDP-glucose, GDP-glucose and GDP-mannose. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Adcock C]] | ||
| + | [[Category: Apostolidou M]] | ||
| + | [[Category: Balikci E]] | ||
| + | [[Category: Bradshaw W]] | ||
| + | [[Category: Feyerherm C]] | ||
| + | [[Category: Huber K]] | ||
| + | [[Category: McGown A]] | ||
| + | [[Category: Spencer J]] | ||
Current revision
Crystal structure of human NUDT14 in complex with a potent inhibitor (MA-955-9)
| |||||||||||
Categories: Homo sapiens | Large Structures | Adcock C | Apostolidou M | Balikci E | Bradshaw W | Feyerherm C | Huber K | McGown A | Spencer J
