9ljy

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Current revision (07:12, 15 October 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9ljy is ON HOLD until Paper Publication
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==Crystal Structure of the Heterodimeric HIF-2 Complex with Agonist SD-14==
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<StructureSection load='9ljy' size='340' side='right'caption='[[9ljy]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9ljy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9LJY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9LJY FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1EJ9:4-chloranyl-1,1-bis(oxidanylidene)-~{N}-(2-pyrrolidin-1-ylphenyl)-1,2-benzothiazol-3-amine'>A1EJ9</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ljy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ljy OCA], [https://pdbe.org/9ljy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ljy RCSB], [https://www.ebi.ac.uk/pdbsum/9ljy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ljy ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ARNT_MOUSE ARNT_MOUSE] Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia (By similarity).
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: Chen X]]
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[[Category: Diao X]]
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[[Category: Li F]]
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[[Category: Wu D]]
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[[Category: Zhuang J]]

Current revision

Crystal Structure of the Heterodimeric HIF-2 Complex with Agonist SD-14

PDB ID 9ljy

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OCA

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