9loh

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Current revision (07:13, 15 October 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9loh is ON HOLD until Paper Publication
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==Crystal Structure of the Heterodimeric HIF-2 Complex with Agonist SD-10==
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<StructureSection load='9loh' size='340' side='right'caption='[[9loh]], [[Resolution|resolution]] 3.02&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9loh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9LOH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9LOH FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.02&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1EJ8:4-fluoranyl-1,1-bis(oxidanylidene)-~{N}-(2-pyrrolidin-1-ylphenyl)-1,2-benzothiazol-3-amine'>A1EJ8</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9loh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9loh OCA], [https://pdbe.org/9loh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9loh RCSB], [https://www.ebi.ac.uk/pdbsum/9loh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9loh ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ARNT_MOUSE ARNT_MOUSE] Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia (By similarity).
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: Chen X]]
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[[Category: Diao X]]
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[[Category: Li F]]
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[[Category: Wu D]]
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[[Category: Zhuang J]]

Current revision

Crystal Structure of the Heterodimeric HIF-2 Complex with Agonist SD-10

PDB ID 9loh

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OCA

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