9y5q

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m (Protected "9y5q" [edit=sysop:move=sysop])
Current revision (07:20, 15 October 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9y5q is ON HOLD
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==Cryo EM structure of KCa3.1_R355K_I/calmodulin channel in complex with rimtuzalcap==
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<StructureSection load='9y5q' size='340' side='right'caption='[[9y5q]], [[Resolution|resolution]] 4.73&Aring;' scene=''>
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Authors: Nam, Y.W., Zhang, M.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9y5q]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9Y5Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9Y5Q FirstGlance]. <br>
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Description: Cryo EM structure of KCa3.1_R355K_I/calmodulin channel in complex with rimtuzalcap
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.73&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1B92:~{N}-[4,4-bis(fluoranyl)cyclohexyl]-2-(3-methylpyrazol-1-yl)-6-morpholin-4-yl-pyrimidin-4-amine'>A1B92</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
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[[Category: Zhang, M]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9y5q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9y5q OCA], [https://pdbe.org/9y5q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9y5q RCSB], [https://www.ebi.ac.uk/pdbsum/9y5q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9y5q ProSAT]</span></td></tr>
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[[Category: Nam, Y.W]]
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/KCNN4_HUMAN KCNN4_HUMAN] The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/KCNN4_HUMAN KCNN4_HUMAN] Forms a voltage-independent potassium channel that is activated by intracellular calcium (PubMed:26148990). Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin (PubMed:17157250, PubMed:18796614).<ref>PMID:17157250</ref> <ref>PMID:18796614</ref> <ref>PMID:26148990</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Nam YW]]
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[[Category: Zhang M]]

Current revision

Cryo EM structure of KCa3.1_R355K_I/calmodulin channel in complex with rimtuzalcap

PDB ID 9y5q

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