9m1i

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Current revision (09:18, 22 October 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9m1i is ON HOLD until Paper Publication
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==Cryo-EM structure of the TBC-D-Arl2-beta-tubulin complex==
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<StructureSection load='9m1i' size='340' side='right'caption='[[9m1i]], [[Resolution|resolution]] 2.48&Aring;' scene=''>
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Authors: Seong, Y.J., Kim, H.M., Byun, K.M., Park, Y.W., Roh, S.H.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9m1i]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9M1I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9M1I FirstGlance]. <br>
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Description: Cryo-EM structure of the TBC-D-Arl2-beta-tubulin complex
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.48&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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[[Category: Byun, K.M]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9m1i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9m1i OCA], [https://pdbe.org/9m1i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9m1i RCSB], [https://www.ebi.ac.uk/pdbsum/9m1i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9m1i ProSAT]</span></td></tr>
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[[Category: Roh, S.H]]
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</table>
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[[Category: Kim, H.M]]
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== Function ==
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[[Category: Seong, Y.J]]
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[https://www.uniprot.org/uniprot/ARL2_HUMAN ARL2_HUMAN] Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction. Participates in association with TBCD, in the disassembly of the apical junction complexes. Antagonizes the effect of TBCD on epithelial cell detachment and tight and adherens junctions disassembly. Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. Component of a regulated secretory pathway involved in Ca(2+)-dependent release of acetylcholine. Required for normal progress through the cell cycle.<ref>PMID:10831612</ref> <ref>PMID:16525022</ref> <ref>PMID:18588884</ref> <ref>PMID:18234692</ref> <ref>PMID:20740604</ref>
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[[Category: Park, Y.W]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Sus scrofa]]
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[[Category: Byun KM]]
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[[Category: Kim HM]]
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[[Category: Park YW]]
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[[Category: Roh SH]]
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[[Category: Seong YJ]]

Current revision

Cryo-EM structure of the TBC-D-Arl2-beta-tubulin complex

PDB ID 9m1i

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