9ub6

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Current revision (09:25, 22 October 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9ub6 is ON HOLD until Paper Publication
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==Crystal structure of SFTSV Gn head with nanobody VHH261==
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<StructureSection load='9ub6' size='340' side='right'caption='[[9ub6]], [[Resolution|resolution]] 2.89&Aring;' scene=''>
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Authors: Wu, Y., Chang, Z., Wu, X.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9ub6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/SFTS_virus_HB29 SFTS virus HB29]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9UB6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9UB6 FirstGlance]. <br>
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Description: Crystal structure of SFTSV Gn head with nanobody VHH261
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.89&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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[[Category: Wu, Y]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ub6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ub6 OCA], [https://pdbe.org/9ub6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ub6 RCSB], [https://www.ebi.ac.uk/pdbsum/9ub6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ub6 ProSAT]</span></td></tr>
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[[Category: Chang, Z]]
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</table>
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[[Category: Wu, X]]
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== Function ==
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[https://www.uniprot.org/uniprot/GP_SFTS GP_SFTS] Structural component of the virion that interacts with glycoprotein C (By similarity). It shields the hydrophobic fusion loops of the glycoprotein C, preventing premature fusion (By similarity). The glycoprotein protrusions are arranged on an icosahedral lattice, with T=12 triangulation (By similarity). They are able to attach the virion to the host cell receptor CD209/DC-SIGN and to promote fusion of membranes with the late endosome after clathrin-mediated endocytosis of the virion (PubMed:23388721). Plays a role in the packaging of ribonucleoproteins during virus assembly (By similarity).[UniProtKB:P09613][UniProtKB:P21401]<ref>PMID:23388721</ref> Structural component of the virion that interacts with glycoprotein N (By similarity). Acts as a class II fusion protein that is activated upon acidification and subsequent repositioning of the glycoprotein N (By similarity). The glycoprotein protrusions are arranged on an icosahedral lattice, with T=12 triangulation (By similarity). They are able to attach the virion to the host cell receptor CD209/DC-SIGN and to promote fusion of membranes with the late endosome after clathrin-mediated endocytosis of the virion (PubMed:23388721).[UniProtKB:P09613][UniProtKB:P21401]<ref>PMID:23388721</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: SFTS virus HB29]]
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[[Category: Chang Z]]
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[[Category: Wu X]]
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[[Category: Wu Y]]

Current revision

Crystal structure of SFTSV Gn head with nanobody VHH261

PDB ID 9ub6

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