9uji

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Current revision (09:25, 22 October 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9uji is ON HOLD until Paper Publication
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==Crystal structure of the BTB domain mouse Keap1 in complex with CDDO-Im==
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<StructureSection load='9uji' size='340' side='right'caption='[[9uji]], [[Resolution|resolution]] 2.44&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9uji]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9UJI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9UJI FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.435&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SXJ:(13ALPHA,18ALPHA)-2-CYANO-3-HYDROXY-12-OXOOLEANA-2,9(11)-DIEN-28-OIC+ACID'>SXJ</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9uji FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9uji OCA], [https://pdbe.org/9uji PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9uji RCSB], [https://www.ebi.ac.uk/pdbsum/9uji PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9uji ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KEAP1_MOUSE KEAP1_MOUSE] Retains NFE2L2/NRF2 in the cytosol. Functions as substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1. Targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. May also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome (By similarity).<ref>PMID:9887101</ref> <ref>PMID:12682069</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: Iso T]]
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[[Category: Mizushima T]]
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[[Category: Suzuki T]]
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[[Category: Takagi K]]
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[[Category: Yamamoto M]]

Current revision

Crystal structure of the BTB domain mouse Keap1 in complex with CDDO-Im

PDB ID 9uji

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