9nyz
From Proteopedia
(Difference between revisions)
m (Protected "9nyz" [edit=sysop:move=sysop]) |
|||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of DCKA/glutamate-bound GluN1/GluN2A agonist binding domains with UCM-101== | |
| - | + | <StructureSection load='9nyz' size='340' side='right'caption='[[9nyz]], [[Resolution|resolution]] 1.71Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9nyz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9NYZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9NYZ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.71Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1B7E:N-(cyclohexylmethyl)-2-[(5-{[(1R)-1-phenylpropyl]amino}-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide'>A1B7E</scene>, <scene name='pdbligand=DK1:5,7-DICHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC+ACID'>DK1</scene>, <scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9nyz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9nyz OCA], [https://pdbe.org/9nyz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9nyz RCSB], [https://www.ebi.ac.uk/pdbsum/9nyz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9nyz ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/NMDZ1_RAT NMDZ1_RAT] NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors.<ref>PMID:15996549</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Rattus norvegicus]] | ||
| + | [[Category: Hansen KB]] | ||
| + | [[Category: Lotti JS]] | ||
| + | [[Category: McClelland LJ]] | ||
| + | [[Category: Syrenne JT]] | ||
| + | [[Category: Yates-Hansen CK]] | ||
Current revision
Crystal structure of DCKA/glutamate-bound GluN1/GluN2A agonist binding domains with UCM-101
| |||||||||||
