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2a0z

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(New page: 200px<br /> <applet load="2a0z" size="450" color="white" frame="true" align="right" spinBox="true" caption="2a0z, resolution 2.400&Aring;" /> '''The molecular stru...)
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Revision as of 18:37, 12 November 2007

Image:2a0z.gif

2a0z, resolution 2.400Å

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The molecular structure of toll-like receptor 3 ligand binding domain

Overview

Innate immunity is the first line of defense against invading pathogens., Toll-like receptors (TLRs) act as sentinels of the innate immune system, sensing a variety of ligands from lipopolysaccharide to flagellin to dsRNA, through their ligand-binding domain that is composed of leucine-rich, repeats (LRRs). Ligand binding initiates a signaling cascade that leads to, the up-regulation of inflammation mediators. In this study, we have, expressed and crystallized the ectodomain (ECD) of human TLR3, which, recognizes dsRNA, a molecular signature of viruses, and have determined, the molecular structure to 2.4-A resolution. The overall horseshoe-shaped, structure of the TLR3-ECD is formed by 23 repeating LRRs that are capped, at each end by specialized non-LRR domains. The extensive beta-sheet on, the molecule's concave surface forms a platform for several modifications, including insertions in the LRRs and 11 N-linked glycans. The TLR3-ECD, structure indicates how LRR loops can establish distinct pathogen, recognition receptors.

About this Structure

2A0Z is a Single protein structure of sequence from Homo sapiens with NAG, GLC, SO4 and BME as ligands. Full crystallographic information is available from OCA.

Reference

The molecular structure of the Toll-like receptor 3 ligand-binding domain., Bell JK, Botos I, Hall PR, Askins J, Shiloach J, Segal DM, Davies DR, Proc Natl Acad Sci U S A. 2005 Aug 2;102(31):10976-80. Epub 2005 Jul 25. PMID:16043704

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