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9yc2

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m (Protected "9yc2" [edit=sysop:move=sysop])
Current revision (07:32, 29 October 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9yc2 is ON HOLD
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==Crystal structure of USP49 ZnF-UBP domain==
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<StructureSection load='9yc2' size='340' side='right'caption='[[9yc2]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
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Authors: Alexandrovics, J.A., Komander, D.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9yc2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9YC2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9YC2 FirstGlance]. <br>
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Description: Crystal structure of USP49 ZnF-UBP domain
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Komander, D]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9yc2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9yc2 OCA], [https://pdbe.org/9yc2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9yc2 RCSB], [https://www.ebi.ac.uk/pdbsum/9yc2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9yc2 ProSAT]</span></td></tr>
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[[Category: Alexandrovics, J.A]]
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/UBP49_HUMAN UBP49_HUMAN] Deubiquitinase that plays a role in several cellular processes including transcriptional regulation, cell cycle progression or innate immunity. Specifically deubiquitinates histone H2B at 'Lys-120' (H2BK120Ub), a specific tag for epigenetic transcriptional activation and acts as a regulator of mRNA splicing (PubMed:23824326). Antagonizes DNA double-strand break-induced ubiquitination of H2AX thereby participating in the maintenance of genome integrity (PubMed:35598681). Plays a role in the negative regulation of cell proliferation through the AKT pathway by deubiquitinating FKBP51, leading to enhanced AKT1 dephosphorylation by PHLPP1 (PubMed:28363942). Also regulates the mitotic spindle checkpoint and prevents aneuploidy (PubMed:36702832). Negatively regulates cellular antiviral responses via deconjugating 'Lys-63'-linked ubiquitination of STING1 (PubMed:30943264). Significantly enhances the anti-HIV-1 activity of APOBEC3G. Mechanistically, stabilizes APOBEC3G by counteracting HIV-1 Vif-mediated APOBEC3G ubiquitination (PubMed:31397674).<ref>PMID:23824326</ref> <ref>PMID:28363942</ref> <ref>PMID:30943264</ref> <ref>PMID:31397674</ref> <ref>PMID:35598681</ref> <ref>PMID:36702832</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Alexandrovics JA]]
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[[Category: Komander D]]

Current revision

Crystal structure of USP49 ZnF-UBP domain

PDB ID 9yc2

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