1ww1

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[[Image:1ww1.gif|left|200px]]
[[Image:1ww1.gif|left|200px]]
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{{Structure
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|PDB= 1ww1 |SIZE=350|CAPTION= <scene name='initialview01'>1ww1</scene>, resolution 2.60&Aring;
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The line below this paragraph, containing "STRUCTURE_1ww1", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Ribonuclease_Z Ribonuclease Z], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.26.11 3.1.26.11] </span>
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{{STRUCTURE_1ww1| PDB=1ww1 | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ww1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ww1 OCA], [http://www.ebi.ac.uk/pdbsum/1ww1 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ww1 RCSB]</span>
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'''Crystal structure of tRNase Z from Thermotoga maritima'''
'''Crystal structure of tRNase Z from Thermotoga maritima'''
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: metallo-beta-lactamase fold]]
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[[Category: Metallo-beta-lactamase fold]]
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[[Category: riken structural genomics/proteomics initiative]]
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[[Category: Riken structural genomics/proteomics initiative]]
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[[Category: rsgi]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:12:42 2008''
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Revision as of 11:12, 3 May 2008

Image:1ww1.gif

Template:STRUCTURE 1ww1

Crystal structure of tRNase Z from Thermotoga maritima


Overview

The maturation of the tRNA 3' end is catalyzed by a tRNA 3' processing endoribonuclease named tRNase Z (RNase Z or 3'-tRNase) in eukaryotes, Archaea, and some bacteria. The tRNase Z generally cuts the 3' extra sequence from the precursor tRNA after the discriminator nucleotide. In contrast, Thermotoga maritima tRNase Z cleaves the precursor tRNA precisely after the CCA sequence. In this study, we determined the crystal structure of T. maritima tRNase Z at 2.6-A resolution. The tRNase Z has a four-layer alphabeta/betaalpha sandwich fold, which is classified as a metallo-beta-lactamase fold, and forms a dimer. The active site is located at one edge of the beta-sandwich and is composed of conserved motifs. Based on the structure, we constructed a docking model with the tRNAs that suggests how tRNase Z may recognize the substrate tRNAs.

About this Structure

1WW1 is a Single protein structure of sequence from Thermotoga maritima. Full crystallographic information is available from OCA.

Reference

Crystal structure of the tRNA 3' processing endoribonuclease tRNase Z from Thermotoga maritima., Ishii R, Minagawa A, Takaku H, Takagi M, Nashimoto M, Yokoyama S, J Biol Chem. 2005 Apr 8;280(14):14138-44. Epub 2005 Jan 27. PMID:15701599 Page seeded by OCA on Sat May 3 14:12:42 2008

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