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9l9t
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of a coronaviral M protein in complex with a C-terminal peptide of the N protein== | |
| + | <StructureSection load='9l9t' size='340' side='right'caption='[[9l9t]], [[Resolution|resolution]] 3.14Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[9l9t]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Pipistrellus_bat_coronavirus_HKU5 Pipistrellus bat coronavirus HKU5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9L9T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9L9T FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.142Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=N8E:3,6,9,12,15-PENTAOXATRICOSAN-1-OL'>N8E</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9l9t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9l9t OCA], [https://pdbe.org/9l9t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9l9t RCSB], [https://www.ebi.ac.uk/pdbsum/9l9t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9l9t ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/VME1_BCHK5 VME1_BCHK5] Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.[HAMAP-Rule:MF_04202][PROSITE-ProRule:PRU01275] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The interaction between the membrane (M) protein and the nucleocapsid (N) protein of coronaviruses plays a crucial role in virus assembly and morphogenesis. Previous studies indicate that one M-N interaction occurs between M protein and the carboxy-terminus of N protein. However, the mechanistic details of M-N interactions remain unclear. Here, we present a complex structure of an N protein carboxy-terminal peptide bound to M protein from Pipistrellus bat coronavirus HKU5. The structure shows that the M-N peptide binding site includes a "horizontal" groove located between the carboxy-terminal domain and the transmembrane domain of M protein. Combined with molecular docking and binding analysis, our results provide structural insight into the binding mechanism between M and N proteins of a coronavirus. | ||
| - | + | Binding of an N protein peptide to M protein of a bat coronavirus.,Wang X, Yang S, Yang P, Sun Z, Zhou X J Struct Biol. 2025 Sep;217(3):108234. doi: 10.1016/j.jsb.2025.108234. Epub 2025 , Jul 13. PMID:40664277<ref>PMID:40664277</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 9l9t" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Pipistrellus bat coronavirus HKU5]] | ||
| + | [[Category: Sun Z]] | ||
| + | [[Category: Wang X]] | ||
| + | [[Category: Zhou X]] | ||
Current revision
Crystal structure of a coronaviral M protein in complex with a C-terminal peptide of the N protein
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