9ye9

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Current revision (09:46, 6 November 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9ye9 is ON HOLD until Paper Publication
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==Structure of UbcH5b in complex with the U-box domain of the E3 ubiquitin ligase CHIP==
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<StructureSection load='9ye9' size='340' side='right'caption='[[9ye9]], [[Resolution|resolution]] 2.01&Aring;' scene=''>
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Authors: Manage, M.M., Nix, J.C., Page, R.C.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9ye9]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9YE9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9YE9 FirstGlance]. <br>
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Description: Structure of UbcH5b in complex with the U-box domain of the E3 ubiquitin ligase CHIP
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.01&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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[[Category: Manage, M.M]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ye9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ye9 OCA], [https://pdbe.org/9ye9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ye9 RCSB], [https://www.ebi.ac.uk/pdbsum/9ye9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ye9 ProSAT]</span></td></tr>
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[[Category: Page, R.C]]
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</table>
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[[Category: Nix, J.C]]
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== Function ==
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[https://www.uniprot.org/uniprot/UB2D2_HUMAN UB2D2_HUMAN] Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection. Essential for viral activation of IRF3.<ref>PMID:10329681</ref> <ref>PMID:15280377</ref> <ref>PMID:18042044</ref> <ref>PMID:18703417</ref> <ref>PMID:18359941</ref> <ref>PMID:19854139</ref> <ref>PMID:20403326</ref> <ref>PMID:20061386</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Danio rerio]]
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Manage MM]]
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[[Category: Nix JC]]
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[[Category: Page RC]]

Current revision

Structure of UbcH5b in complex with the U-box domain of the E3 ubiquitin ligase CHIP

PDB ID 9ye9

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