1wyk

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[[Image:1wyk.jpg|left|200px]]
[[Image:1wyk.jpg|left|200px]]
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{{Structure
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|PDB= 1wyk |SIZE=350|CAPTION= <scene name='initialview01'>1wyk</scene>, resolution 2.0&Aring;
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The line below this paragraph, containing "STRUCTURE_1wyk", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=DIO:1,4-DIETHYLENE+DIOXIDE'>DIO</scene>, <scene name='pdbligand=FOR:FORMYL+GROUP'>FOR</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= POTENTIAL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11034 Sindbis virus])
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|DOMAIN=
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{{STRUCTURE_1wyk| PDB=1wyk | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wyk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wyk OCA], [http://www.ebi.ac.uk/pdbsum/1wyk PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1wyk RCSB]</span>
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'''SINDBIS VIRUS CAPSID PROTEIN (114-264)'''
'''SINDBIS VIRUS CAPSID PROTEIN (114-264)'''
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[[Category: Lee, S.]]
[[Category: Lee, S.]]
[[Category: Rossmann, M G.]]
[[Category: Rossmann, M G.]]
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[[Category: alphavirus]]
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[[Category: Alphavirus]]
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[[Category: capsid]]
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[[Category: Capsid]]
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[[Category: coat protein]]
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[[Category: Coat protein]]
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[[Category: dioxane]]
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[[Category: Dioxane]]
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[[Category: proteinase]]
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[[Category: Proteinase]]
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[[Category: sindbi]]
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[[Category: Sindbi]]
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[[Category: virus]]
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[[Category: Virus]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:18:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:42:39 2008''
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Revision as of 11:18, 3 May 2008

Image:1wyk.jpg

Template:STRUCTURE 1wyk

SINDBIS VIRUS CAPSID PROTEIN (114-264)


Overview

Alphavirus budding from the plasma membrane is initiated by the specific interaction of the nucleocapsid with the cytoplasmic domain of the glycoprotein E2. It was proposed (Lee et al., Structure 4:531-541, 1996) that binding of the capsid protein residues 108 to 110 (the "N-terminal arm" residues) to a hydrophobic pocket on the surface of the neighboring capsid protein in the crystal structure mimics the binding of the E2 C-terminal residues into this pocket. In addition, structural comparisons of wild-type and mutant Sindbis virus capsid protein (SCP) and Semliki Forest virus capsid protein suggested that budding is associated with a switch between two conformations of the hydrophobic pocket. To test the proposed mechanism, SCP(114-264), which is missing the N-terminal arm, was crystallized to examine the pocket conformation when the pocket is empty. However, the pocket was occupied by dioxane molecules from the crystallization solution. The pocket conformation was the same as that when it was occupied by the N-terminal arm, demonstrating that the pocket favors binding ligands of appropriate size and shape.

About this Structure

1WYK is a Single protein structure of sequence from Sindbis virus. Full crystallographic information is available from OCA.

Reference

Probing the potential glycoprotein binding site of sindbis virus capsid protein with dioxane and model building., Lee S, Kuhn RJ, Rossmann MG, Proteins. 1998 Nov 1;33(2):311-7. PMID:9779796 Page seeded by OCA on Sat May 3 14:18:42 2008

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