9oc7
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of FcRn in complex with Human Astrovirus 2 spike== | |
| - | + | <StructureSection load='9oc7' size='340' side='right'caption='[[9oc7]], [[Resolution|resolution]] 3.07Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9oc7]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_astrovirus_2 Human astrovirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9OC7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9OC7 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.07Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9oc7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9oc7 OCA], [https://pdbe.org/9oc7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9oc7 RCSB], [https://www.ebi.ac.uk/pdbsum/9oc7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9oc7 ProSAT]</span></td></tr> |
| - | [[Category: Agrawal | + | </table> |
| - | [[Category: Wilson | + | == Function == |
| + | [https://www.uniprot.org/uniprot/CAPSD_HASV2 CAPSD_HASV2] The capsid polyprotein VP90 self-assembles and undergoes a proteolytic cleavage by host caspases to yield the VP70 virions. This immature virion is composed of 180 VP70 subunits with 90 dimeric spikes and displays a T=3 icosahedral symmetry. The mature virion is obtained by further cleavages resulting in three structural proteins VP25, VP27 and VP34. This forms contains only 30 spikes located on the icosahedral 2-fold axes. Plays a role in the attachment to target host cell. This attachment induces virion internalization through clathrin-dependent endocytosis (By similarity). | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Human astrovirus 2]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Agrawal S]] | ||
| + | [[Category: Wilson IA]] | ||
Current revision
Crystal structure of FcRn in complex with Human Astrovirus 2 spike
| |||||||||||
