9uyl

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m (Protected "9uyl" [edit=sysop:move=sysop])
Current revision (07:52, 19 November 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9uyl is ON HOLD until Paper Publication
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==Cryo-EM structure of the G protein-coupled receptor 1 (GPR1) bound to chemerin and beta-arrestin 1 (Conformation 4)==
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<StructureSection load='9uyl' size='340' side='right'caption='[[9uyl]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9uyl]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_phage_EcSzw-2 Escherichia phage EcSzw-2] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9UYL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9UYL FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9uyl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9uyl OCA], [https://pdbe.org/9uyl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9uyl RCSB], [https://www.ebi.ac.uk/pdbsum/9uyl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9uyl ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/V2R_HUMAN V2R_HUMAN] Nephrogenic syndrome of inappropriate antidiuresis;Inappropriate antidiuretic hormone secretion syndrome;Nephrogenic diabetes insipidus. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/CML2_HUMAN CML2_HUMAN] Receptor for chemoattractant adipokine chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation and energy homesotasis (PubMed:18165312, PubMed:27716822). Signals mainly via beta-arrestin pathway. Binding of RARRES2 activates weakly G proteins, calcium mobilization and MAPK1/MAPK3 (ERK1/2) phosphorylation too (PubMed:27716822). Acts also as a receptor for TAFA1, mediates its effects on neuronal stem-cell proliferation and differentiation via the activation of ROCK/ERK and ROCK/STAT3 signaling pathway (By similarity).[UniProtKB:Q8K087]<ref>PMID:18165312</ref> <ref>PMID:27716822</ref> (Microbial infection) Coreceptor for HIV-1.<ref>PMID:10233994</ref> [https://www.uniprot.org/uniprot/V2R_HUMAN V2R_HUMAN] Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption.<ref>PMID:19440390</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Escherichia phage EcSzw-2]]
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Cai H]]
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[[Category: He M]]
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[[Category: Lin X]]
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[[Category: Ma Y]]
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[[Category: Shui W]]
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[[Category: Wu B]]
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[[Category: Xie C]]
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[[Category: Yu J]]
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[[Category: Zhang B]]
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[[Category: Zhao L]]
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[[Category: Zhao Q]]
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[[Category: Zhu Y]]

Current revision

Cryo-EM structure of the G protein-coupled receptor 1 (GPR1) bound to chemerin and beta-arrestin 1 (Conformation 4)

PDB ID 9uyl

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OCA

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