9vca
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Binding site between C-reactive protein and c2cc monoclonal antibody== | |
| + | <StructureSection load='9vca' size='340' side='right'caption='[[9vca]], [[Resolution|resolution]] 2.40Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[9vca]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus_albula Mus musculus albula]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9VCA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9VCA FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.4Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9vca FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9vca OCA], [https://pdbe.org/9vca PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9vca RCSB], [https://www.ebi.ac.uk/pdbsum/9vca PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9vca ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CRP_HUMAN CRP_HUMAN] Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | C-reactive protein (CRP) plays a central role in innate immunity and serves as a key biomarker of inflammation. Despite its clinical importance, the structural basis of CRP interactions with antibodies remains poorly characterized. Using cryo-electron microscopy (cryo-EM), we resolved the structure of immune complexes formed between pentameric CRP and monoclonal immunoglobulin G (IgG) antibodies at up to 2.4 A resolution. The complexes display a barrel-shaped architecture, with two CRP pentamers bridged by three to five antibodies. We built an atomic model of the CRP-antibody interface, identifying a binding site on the A-face of CRP mediated exclusively by hydrogen bonds, without salt-bridge formation. These findings provide structural insights into CRP-IgG recognition and offer a basis for the rational design of improved antibodies. | ||
| - | + | Cryo-EM structure of pentameric C-reactive protein in complex with monoclonal IgG antibodies.,Moiseenko AV, Kalikin AV, Orekhov PS, Byzova NA, Zherdev AV, Shaitan KV, Dzantiev BB, Sokolova OS FEBS J. 2025 Oct 29. doi: 10.1111/febs.70310. PMID:41159871<ref>PMID:41159871</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: Kalikin | + | <div class="pdbe-citations 9vca" style="background-color:#fffaf0;"></div> |
| - | [[Category: Moiseenko | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus albula]] | ||
| + | [[Category: Kalikin AV]] | ||
| + | [[Category: Moiseenko AV]] | ||
Current revision
Binding site between C-reactive protein and c2cc monoclonal antibody
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