1wyy
From Proteopedia
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[[Image:1wyy.gif|left|200px]] | [[Image:1wyy.gif|left|200px]] | ||
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'''Post-fusion hairpin conformation of the sars coronavirus spike glycoprotein''' | '''Post-fusion hairpin conformation of the sars coronavirus spike glycoprotein''' | ||
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[[Category: Rottier, P J.M.]] | [[Category: Rottier, P J.M.]] | ||
[[Category: Vigouroux, A.]] | [[Category: Vigouroux, A.]] | ||
| - | [[Category: | + | [[Category: Coiled coil]] |
| - | [[Category: | + | [[Category: Membrane fusion]] |
| - | [[Category: | + | [[Category: Severe acute respiratory syndrome]] |
| - | [[Category: | + | [[Category: Viral protein]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:19:47 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 11:19, 3 May 2008
Post-fusion hairpin conformation of the sars coronavirus spike glycoprotein
Overview
The coronavirus spike glycoprotein is a class I membrane fusion protein with two characteristic heptad repeat regions (HR1 and HR2) in its ectodomain. Here, we report the X-ray structure of a previously characterized HR1/HR2 complex of the severe acute respiratory syndrome coronavirus spike protein. As expected, the HR1 and HR2 segments are organized in antiparallel orientations within a rod-like molecule. The HR1 helices form an exceptionally long (120 A) internal coiled coil stabilized by hydrophobic and polar interactions. A striking arrangement of conserved asparagine and glutamine residues of HR1 propagates from two central chloride ions, providing hydrogen-bonding "zippers" that strongly constrain the path of the HR2 main chain, forcing it to adopt an extended conformation at either end of a short HR2 alpha-helix.
About this Structure
1WYY is a Single protein structure of sequence from Human sars coronavirus. Full crystallographic information is available from OCA.
Reference
Central ions and lateral asparagine/glutamine zippers stabilize the post-fusion hairpin conformation of the SARS coronavirus spike glycoprotein., Duquerroy S, Vigouroux A, Rottier PJ, Rey FA, Bosch BJ, Virology. 2005 May 10;335(2):276-85. PMID:15840526 Page seeded by OCA on Sat May 3 14:19:47 2008
