1wza

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[[Image:1wza.gif|left|200px]]
[[Image:1wza.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1wza |SIZE=350|CAPTION= <scene name='initialview01'>1wza</scene>, resolution 1.60&Aring;
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The line below this paragraph, containing "STRUCTURE_1wza", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Alpha-amylase Alpha-amylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.1 3.2.1.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= AMYA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=31909 Halothermothrix orenii])
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-->
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|DOMAIN=
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{{STRUCTURE_1wza| PDB=1wza | SCENE= }}
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|RELATEDENTRY=[[1gvi|1GVI]], [[1sma|1SMA]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wza OCA], [http://www.ebi.ac.uk/pdbsum/1wza PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1wza RCSB]</span>
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}}
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'''Crystal structure of alpha-amylase from H.orenii'''
'''Crystal structure of alpha-amylase from H.orenii'''
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[[Category: Sivakumar, N.]]
[[Category: Sivakumar, N.]]
[[Category: Swaminathan, K.]]
[[Category: Swaminathan, K.]]
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[[Category: alpha amylase]]
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[[Category: Alpha amylase]]
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[[Category: halophilic]]
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[[Category: Halophilic]]
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[[Category: halothermothrix orenii]]
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[[Category: Halothermothrix orenii]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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[[Category: thermophilic]]
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[[Category: Thermophilic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:20:29 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:42:56 2008''
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Revision as of 11:20, 3 May 2008

Image:1wza.gif

Template:STRUCTURE 1wza

Crystal structure of alpha-amylase from H.orenii


Overview

Here we report the first crystal structure of a protein, AmyA, a secretory alpha-amylase isolated from Halothermothrix orenii, which is both halophilic and thermophilic. The crystal structure was determined at 1.6 A resolution. AmyA lacks the conserved acidic surface, which is considered essential for protein stability at high salinity. Sedimentation velocity and CD experiments on AmyA reveal the formation of unique reversible poly-dispersed oligomers that show unusually high thermal stability. These studies provide valuable insight into the structural elements that contribute to the stability of AmyA at both physical and chemical extremes and their functional implications.

About this Structure

1WZA is a Single protein structure of sequence from Halothermothrix orenii. Full crystallographic information is available from OCA.

Reference

Crystal structure of AmyA lacks acidic surface and provide insights into protein stability at poly-extreme condition., Sivakumar N, Li N, Tang JW, Patel BK, Swaminathan K, FEBS Lett. 2006 May 15;580(11):2646-52. Epub 2006 Apr 19. PMID:16647060 Page seeded by OCA on Sat May 3 14:20:29 2008

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