9l9i

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Current revision (06:25, 26 November 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9l9i is ON HOLD until Paper Publication
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==Crystal structure of ARMS 1-4 ARs in complex with GABARAP==
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<StructureSection load='9l9i' size='340' side='right'caption='[[9l9i]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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Authors: Jiang, W.L., Chen, J.S., Wang, C.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9l9i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9L9I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9L9I FirstGlance]. <br>
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Description: Crystal structure of ARMS 1-4 ARs in complex with GABARAP
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9l9i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9l9i OCA], [https://pdbe.org/9l9i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9l9i RCSB], [https://www.ebi.ac.uk/pdbsum/9l9i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9l9i ProSAT]</span></td></tr>
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[[Category: Jiang, W.L]]
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</table>
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[[Category: Wang, C]]
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== Function ==
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[[Category: Chen, J.S]]
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[https://www.uniprot.org/uniprot/KDIS_RAT KDIS_RAT] Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration.<ref>PMID:11150334</ref> <ref>PMID:15167895</ref> <ref>PMID:15939763</ref> <ref>PMID:17724123</ref> [https://www.uniprot.org/uniprot/GBRAP_RAT GBRAP_RAT] Involved in apoptosis (By similarity). May play a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Involved in autophagy (By similarity).<ref>PMID:11461150</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Rattus norvegicus]]
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[[Category: Chen JS]]
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[[Category: Jiang WL]]
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[[Category: Wang C]]

Current revision

Crystal structure of ARMS 1-4 ARs in complex with GABARAP

PDB ID 9l9i

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