9ogo

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "9ogo" [edit=sysop:move=sysop])
Current revision (06:31, 26 November 2025) (edit) (undo)
 
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 9ogo is ON HOLD
+
==Crystal Structure of KPT185 in complex with CRM1(EH mutant)-Ran-RanBP1==
-
 
+
<StructureSection load='9ogo' size='340' side='right'caption='[[9ogo]], [[Resolution|resolution]] 2.37&Aring;' scene=''>
-
Authors: Fung, H.Y.J., Chook, Y.M.
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[9ogo]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] and [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9OGO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9OGO FirstGlance]. <br>
-
Description: Crystal Structure of KPT185 in complex with CRM1(EH mutant)-Ran-RanBP1
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.37&#8491;</td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=K85:PROPAN-2-YL+3-{3-[3-METHOXY-5-(TRIFLUOROMETHYL)PHENYL]-1H-1,2,4-TRIAZOL-1-YL}PROPANOATE'>K85</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-
[[Category: Chook, Y.M]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ogo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ogo OCA], [https://pdbe.org/9ogo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ogo RCSB], [https://www.ebi.ac.uk/pdbsum/9ogo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ogo ProSAT]</span></td></tr>
-
[[Category: Fung, H.Y.J]]
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/RAN_HUMAN RAN_HUMAN] GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity). The complex with BIRC5/ survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2.<ref>PMID:10400640</ref> <ref>PMID:8692944</ref> <ref>PMID:18591255</ref> <ref>PMID:18617507</ref> Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases.<ref>PMID:10400640</ref> <ref>PMID:8692944</ref> <ref>PMID:18591255</ref> <ref>PMID:18617507</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Homo sapiens]]
 +
[[Category: Large Structures]]
 +
[[Category: Saccharomyces cerevisiae]]
 +
[[Category: Saccharomyces cerevisiae S288C]]
 +
[[Category: Chook YM]]
 +
[[Category: Fung HYJ]]

Current revision

Crystal Structure of KPT185 in complex with CRM1(EH mutant)-Ran-RanBP1

PDB ID 9ogo

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/9ogo"
Personal tools