9w4n

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Current revision (06:37, 26 November 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9w4n is ON HOLD until Paper Publication
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==Structure of rat TRPV1 in complex with SB-366791==
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<StructureSection load='9w4n' size='340' side='right'caption='[[9w4n]], [[Resolution|resolution]] 3.25&Aring;' scene=''>
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Authors: Chen, X., Yu, Y.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9w4n]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9W4N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9W4N FirstGlance]. <br>
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Description: Structure of rat TRPV1 in complex with SB-366791
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.25&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZEI:(~{E})-3-(4-chlorophenyl)-~{N}-(3-methoxyphenyl)prop-2-enamide'>ZEI</scene></td></tr>
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[[Category: Yu, Y]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9w4n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9w4n OCA], [https://pdbe.org/9w4n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9w4n RCSB], [https://www.ebi.ac.uk/pdbsum/9w4n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9w4n ProSAT]</span></td></tr>
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[[Category: Chen, X]]
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TRPV1_RAT TRPV1_RAT] Receptor-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. May be involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits a time- and Ca(2+)-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH <6) directly activate the channel. Can be activated by endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis.<ref>PMID:9349813</ref> <ref>PMID:10644739</ref> <ref>PMID:11140687</ref> <ref>PMID:11418861</ref> <ref>PMID:12095983</ref> <ref>PMID:12194871</ref> <ref>PMID:12808128</ref> <ref>PMID:14523239</ref> <ref>PMID:12764195</ref> <ref>PMID:14630912</ref> <ref>PMID:15173182</ref> <ref>PMID:21076423</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Rattus norvegicus]]
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[[Category: Chen X]]
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[[Category: Yu Y]]

Current revision

Structure of rat TRPV1 in complex with SB-366791

PDB ID 9w4n

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