9x8s
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the human GAS41 YEATS domain in complex with an acetylated YFV capsid peptide (K4ac)== | |
| - | + | <StructureSection load='9x8s' size='340' side='right'caption='[[9x8s]], [[Resolution|resolution]] 1.70Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9x8s]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Yellow_fever_virus Yellow fever virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9X8S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9X8S FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.696Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene></td></tr> |
| - | [[Category: Chen | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9x8s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9x8s OCA], [https://pdbe.org/9x8s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9x8s RCSB], [https://www.ebi.ac.uk/pdbsum/9x8s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9x8s ProSAT]</span></td></tr> |
| - | [[Category: Kang | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/YETS4_HUMAN YETS4_HUMAN] Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.<ref>PMID:14966270</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Yellow fever virus]] | ||
| + | [[Category: Chen SDC]] | ||
| + | [[Category: Kang SSK]] | ||
Current revision
Crystal structure of the human GAS41 YEATS domain in complex with an acetylated YFV capsid peptide (K4ac)
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