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Revision as of 08:07, 29 November 2025

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Contents 1 Structure 2 Function 3 Disease relevance 4 Structural highlights 5 References

Structure

spinqualitylabelsall models Cryo-EM structure of human Vangl1 (PDB: 8ZXD) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

This page describes the cryo-EM structure of the human planar cell polarity (PCP) core protein **Vangl1**, determined at high resolution and deposited as **PDB ID: 8ZXD**. The structure reveals the oligomeric assembly and membrane-embedded architecture of Vangl1.

Function

Vangl1 is a core component of the **planar cell polarity pathway**, required for the asymmetric organization of epithelial cells. It interacts with other PCP proteins such as Prickle, Dishevelled, and Celsr, helping establish directional cues during development.

Disease relevance

Mutations in Vangl1 are associated with **neural tube defects**, disrupted epithelial morphogenesis, and defects in directional cell movement. Understanding the structure of Vangl1 (8ZXD) provides insights into how disease-causing mutations impair PCP signaling.

Structural highlights

• The 8ZXD cryo-EM structure reveals Vangl1 forms a **stable oligomeric assembly**. • Multiple **transmembrane helices** form a curved architecture suited for membrane integration. • The **cytoplasmic C-terminal tail** contains potential interaction motifs for PCP partners. • Structural comparisons indicate how mutations may disrupt folding, oligomerization, or partner binding.

References

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