1x0s

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[[Image:1x0s.gif|left|200px]]
[[Image:1x0s.gif|left|200px]]
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{{Structure
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|PDB= 1x0s |SIZE=350|CAPTION= <scene name='initialview01'>1x0s</scene>, resolution 2.50&Aring;
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The line below this paragraph, containing "STRUCTURE_1x0s", creates the "Structure Box" on the page.
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|LIGAND= <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GLC:GLUCOSE'>GLC</scene>, <scene name='pdbligand=L2P:2,3-DI-PHYTANYL-GLYCEROL'>L2P</scene>, <scene name='pdbligand=L3P:2,3-DI-O-PHYTANLY-3-SN-GLYCERO-1-PHOSPHORYL-3&#39;-SN-GLYCEROL-1&#39;-PHOSPHATE'>L3P</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=RET:RETINAL'>RET</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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{{STRUCTURE_1x0s| PDB=1x0s | SCENE= }}
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|RELATEDENTRY=[[1iw6|1iw6]], [[1x0i|1X0I]], [[1x0k|1X0K]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1x0s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x0s OCA], [http://www.ebi.ac.uk/pdbsum/1x0s PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1x0s RCSB]</span>
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'''Crystal structure of the 13-cis isomer of bacteriorhodopsin'''
'''Crystal structure of the 13-cis isomer of bacteriorhodopsin'''
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[[Category: Murakami, M.]]
[[Category: Murakami, M.]]
[[Category: Nishikawa, T.]]
[[Category: Nishikawa, T.]]
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[[Category: memebrane protein]]
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[[Category: Memebrane protein]]
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[[Category: proton pump]]
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[[Category: Proton pump]]
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[[Category: retinal]]
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[[Category: Retinal]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:23:18 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:43:26 2008''
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Revision as of 11:23, 3 May 2008

Template:STRUCTURE 1x0s

Crystal structure of the 13-cis isomer of bacteriorhodopsin


Overview

The atomic structure of the trans isomer of bacteriorhodopsin was determined previously by using a 3D crystal belonging to the space group P622. Here, a structure is reported for another isomer with the 13-cis, 15-syn retinal in a dark-adapted crystal. Structural comparison of the two isomers indicates that retinal isomerization around the C13[double bond]C14 and the C15[double bond]N bonds is accompanied by noticeable displacements of a few residues in the vicinity of the retinal Schiff base and small re-arrangement of the hydrogen-bonding network in the proton release channel. On the other hand, aromatic residues surrounding the retinal polyene chain were found to scarcely move during the dark/light adaptation. This result suggests that variation in the structural rigidity within the retinal-binding pocket is one of the important factors ensuring the stereospecific isomerization of retinal.

About this Structure

1X0S is a Single protein structure of sequence from Halobacterium salinarum. Full crystallographic information is available from OCA.

Reference

Crystal structure of the 13-cis isomer of bacteriorhodopsin in the dark-adapted state., Nishikawa T, Murakami M, Kouyama T, J Mol Biol. 2005 Sep 16;352(2):319-28. PMID:16084526 Page seeded by OCA on Sat May 3 14:23:18 2008

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