1x0s
From Proteopedia
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[[Image:1x0s.gif|left|200px]] | [[Image:1x0s.gif|left|200px]] | ||
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'''Crystal structure of the 13-cis isomer of bacteriorhodopsin''' | '''Crystal structure of the 13-cis isomer of bacteriorhodopsin''' | ||
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[[Category: Murakami, M.]] | [[Category: Murakami, M.]] | ||
[[Category: Nishikawa, T.]] | [[Category: Nishikawa, T.]] | ||
- | [[Category: | + | [[Category: Memebrane protein]] |
- | [[Category: | + | [[Category: Proton pump]] |
- | [[Category: | + | [[Category: Retinal]] |
- | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:23:18 2008'' | |
- | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + |
Revision as of 11:23, 3 May 2008
Crystal structure of the 13-cis isomer of bacteriorhodopsin
Overview
The atomic structure of the trans isomer of bacteriorhodopsin was determined previously by using a 3D crystal belonging to the space group P622. Here, a structure is reported for another isomer with the 13-cis, 15-syn retinal in a dark-adapted crystal. Structural comparison of the two isomers indicates that retinal isomerization around the C13[double bond]C14 and the C15[double bond]N bonds is accompanied by noticeable displacements of a few residues in the vicinity of the retinal Schiff base and small re-arrangement of the hydrogen-bonding network in the proton release channel. On the other hand, aromatic residues surrounding the retinal polyene chain were found to scarcely move during the dark/light adaptation. This result suggests that variation in the structural rigidity within the retinal-binding pocket is one of the important factors ensuring the stereospecific isomerization of retinal.
About this Structure
1X0S is a Single protein structure of sequence from Halobacterium salinarum. Full crystallographic information is available from OCA.
Reference
Crystal structure of the 13-cis isomer of bacteriorhodopsin in the dark-adapted state., Nishikawa T, Murakami M, Kouyama T, J Mol Biol. 2005 Sep 16;352(2):319-28. PMID:16084526 Page seeded by OCA on Sat May 3 14:23:18 2008