TRPC1 TRPC4 8WPL BI3323 Aug2025

From Proteopedia

Revision as of 01:39, 29 November 2025 (edit) Mari Debbarma (Talk | contribs) (Initial page creation for Sandbox_TRPC1_TRPC4_8PWL) ← Previous diff

Revision as of 12:39, 30 November 2025 (edit) (undo) Mari Debbarma (Talk | contribs) m (Sandbox TRPC1 TRPC4 8WPL moved to TRPC1 TRPC4 8WPL BI3323 Aug2025) Next diff →

---

Revision as of 12:39, 30 November 2025

proteopedia linkproteopedia link

Overview of the TRPC1/TRPC4 Channel

spinqualitylabelsall models Cryo-EM structure of the heteromeric human TRPC1/TRPC4 channel (PDB: 8WPL) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image This is a default text for your page Sandbox TRPC1 TRPC4 8WPL. Click above on edit this page to modify. Be careful with the < and > signs. You may include any references to papers as in: the use of JSmol in Proteopedia [1] or to the article describing Jmol [2] to the rescue. == Function == 1.TRCP1 helps the cell to fill up for SERCA2 deficiency so that the cell can survive by letting more calcium enter the endoplasmic reticulum. This activates survival pathways, such as NF-kB, reduces cell death, and promotes cell growth.[3] 2) when TRPC1 joins TRPC4 channel (1 TRPC1 and TRPC4) it pushes away Ca²⁺ as TRPC1 has an aminio acid(K639) which is positively charged pushing the positively charged calcium. It also develops more preference for Na⁺/K⁺ over Ca²⁺, while increasing inhibitor sensitivity.[4] 3. TRPC4 is essential during early postnatal brain development, as it helps dendrites grow and stay stable by turning glutamate signals into calcium entry, activating a force-generating pathway. Without TRPC4, dendrites will disintegrate.[5] Disease Relevance Structural highlights

References

1. ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
2. ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
3. ↑ Pani, B., Cornatzer, E. et al. (2006). Up-Regulation of Transient Receptor Potential Canonical 1 (TRPC1) following Sarco(endo)plasmic Reticulum Ca²⁺ ATPase 2 Gene Silencing Promotes Cell Survival: A Potential Role for TRPC1 in Darier's Disease. Molecular Biology of the Cell, 17(10):4446–4458.
4. ↑ Won, J., Kim, J., Kim, J. et al. (2025). Cryo-EM structure of the heteromeric TRPC1/TRPC4 channel. Nature Structural & Molecular Biology, 32(2):326–338. DOI: 10.1038/s41594-024-01408-1
5. ↑ Jeon, J., Moore, T. I., Sob, I. et al. (2025). TRPC4 regulates limbic behavior and neuronal development by stabilizing dendrite branches through actomyosin-driven integrin activation. PNAS, 122(33):e2511037ca122.