9eg1

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Current revision (19:13, 4 December 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9eg1 is ON HOLD until Paper Publication
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==COP9 signalosome deneddylation complex with cullin-5==
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<StructureSection load='9eg1' size='340' side='right'caption='[[9eg1]], [[Resolution|resolution]] 3.52&Aring;' scene=''>
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Authors: Shi, H., Zheng, N.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9eg1]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9EG1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9EG1 FirstGlance]. <br>
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Description: COP9 signalosome deneddylation complex with cullin-5
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.52&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Shi, H]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9eg1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9eg1 OCA], [https://pdbe.org/9eg1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9eg1 RCSB], [https://www.ebi.ac.uk/pdbsum/9eg1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9eg1 ProSAT]</span></td></tr>
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[[Category: Zheng, N]]
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CSN2_HUMAN CSN2_HUMAN] Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1.<ref>PMID:9535219</ref> <ref>PMID:11285227</ref> <ref>PMID:11337588</ref> <ref>PMID:12732143</ref> <ref>PMID:12628923</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Shi H]]
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[[Category: Zheng N]]

Current revision

COP9 signalosome deneddylation complex with cullin-5

PDB ID 9eg1

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