1x1z

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[[Image:1x1z.gif|left|200px]]
[[Image:1x1z.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1x1z |SIZE=350|CAPTION= <scene name='initialview01'>1x1z</scene>, resolution 1.45&Aring;
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The line below this paragraph, containing "STRUCTURE_1x1z", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=BMP:6-HYDROXYURIDINE-5&#39;-PHOSPHATE'>BMP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Orotidine-5'-phosphate_decarboxylase Orotidine-5'-phosphate decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.23 4.1.1.23] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1x1z| PDB=1x1z | SCENE= }}
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|RELATEDENTRY=[[1dv7|1DV7]], [[1dvj|1DVJ]], [[1kly|1KLY]], [[1klz|1KLZ]], [[1km0|1KM0]], [[1km1|1KM1]], [[1km2|1KM2]], [[1km3|1KM3]], [[1km4|1KM4]], [[1km5|1KM5]], [[1km6|1KM6]], [[1lol|1LOL]], [[1loq|1LOQ]], [[1lor|1LOR]], [[1los|1LOS]], [[1lp6|1LP6]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1x1z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x1z OCA], [http://www.ebi.ac.uk/pdbsum/1x1z PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1x1z RCSB]</span>
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}}
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'''Orotidine 5'-monophosphate decarboxylase (odcase) complexed with BMP (produced from 6-cyanoump)'''
'''Orotidine 5'-monophosphate decarboxylase (odcase) complexed with BMP (produced from 6-cyanoump)'''
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[[Category: Wei, L.]]
[[Category: Wei, L.]]
[[Category: 6-cyanoump]]
[[Category: 6-cyanoump]]
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[[Category: barbituric acid ribosyl 5'-monophosphate (bmp)]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:25:43 2008''
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[[Category: orotidine 5'-monophosphate decarboxylase (odcase)]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:43:47 2008''
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Revision as of 11:25, 3 May 2008

Template:STRUCTURE 1x1z

Orotidine 5'-monophosphate decarboxylase (odcase) complexed with BMP (produced from 6-cyanoump)


Overview

Orotidine-5'-monophosphate decarboxylase (ODCase) has evolved to catalyze a decarboxylation reaction, most probably via a carbanion species at the C6 position of orotidine-5'-monophosphate. We reveal an unusual biochemical pathway of conversion of 6-cyano-uridine-5'-monophosphate by ODCase to barbiturate-5'-monophosphate via perhaps an electrophilic center at the C6 position, leading to inhibition. This potential of ODCase is very useful in the design of novel inhibitors.

About this Structure

1X1Z is a Single protein structure of sequence from Methanothermobacter thermautotrophicus. Full crystallographic information is available from OCA.

Reference

An unprecedented twist to ODCase catalytic activity., Fujihashi M, Bello AM, Poduch E, Wei L, Annedi SC, Pai EF, Kotra LP, J Am Chem Soc. 2005 Nov 2;127(43):15048-50. PMID:16248642 Page seeded by OCA on Sat May 3 14:25:43 2008

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