9ph4

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Current revision (19:29, 4 December 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 9ph4 is ON HOLD until Paper Publication
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==Cryo-EM structure of COP9 signalosome in complex with CSN5i-1a==
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<StructureSection load='9ph4' size='340' side='right'caption='[[9ph4]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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Authors: Shi, H., Zheng, N.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[9ph4]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9PH4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9PH4 FirstGlance]. <br>
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Description: Cryo-EM structure of COP9 signalosome in complex with CSN5i-1a
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1CH3:6-[(4R,5S,6S)-6-hydroxy-6,7,8,9-tetrahydro-5H-imidazo[1,5-a]azepin-5-yl][1,1-biphenyl]-3-carbonitrile'>A1CH3</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Shi, H]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ph4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ph4 OCA], [https://pdbe.org/9ph4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ph4 RCSB], [https://www.ebi.ac.uk/pdbsum/9ph4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ph4 ProSAT]</span></td></tr>
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[[Category: Zheng, N]]
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CSN1_HUMAN CSN1_HUMAN] Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction.<ref>PMID:9535219</ref> <ref>PMID:11285227</ref> <ref>PMID:11337588</ref> <ref>PMID:12732143</ref> <ref>PMID:12628923</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Shi H]]
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[[Category: Zheng N]]

Current revision

Cryo-EM structure of COP9 signalosome in complex with CSN5i-1a

PDB ID 9ph4

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OCA

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